Evidence map›Paper›PMID 29785069›Full record

ArticleBioinformation2018

Genetic characterization of Chikungunya virus 2009 isolates from South India.

Gopalsamy Sarangan, Seema A Nayar, Monika Mani, Sudharsana Sundarrajan, Sathish Sankar, Gunasekaran Palani, Gracy Fathima Selvaraj, Jayachandran Damodharan, Karuppaiah Muthumani, Padma Srikanth

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Current Status of Chikungunya in India.Frontiers in microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Gopalsamy SaranganDepartment of Microbiology, Sri Ramachandra Medical College and Research Institute, Chennai, India.
Seema A NayarDepartment of Microbiology, Trivandrum Medical College, Trivandrum, India.
Monika ManiDepartment of Microbiology, Sri Ramachandra Medical College and Research Institute, Chennai, India.
Sudharsana SundarrajanDepartment of Biotechnology, Vellore Institute of Technology, Vellore, India.
Sathish SankarSri Sakthi Amma Institute of Biomedical Research Sri Narayani Hospital and Research Centre, Sripuram, India.
Gunasekaran PalaniDepartment of Virology, King Institute of Preventive Medicine, India.
Gracy Fathima SelvarajDepartment of Virology, King Institute of Preventive Medicine, India.
Jayachandran DamodharanSaveetha Institute of Medical and Technical Sciences, Chennai, India.
Karuppaiah MuthumaniThe Wistar Institute, Philadelphia, USA.
Padma SrikanthDepartment of Microbiology, Sri Ramachandra Medical College and Research Institute, Chennai, India.
Sri Ramachandra Institute of Higher Education and Research · INKing Institute of Preventive Medicine and Research · INSaveetha University · INSri Narayani Hospital & Research Centre · INThe Wistar Institute · USVellore Institute of Technology University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chikungunya Virus (CHIKV) is a single stranded positive sense enveloped RNA virus. Re-emergence of CHIKV caused a massive outbreak with severe clinical manifestation affecting multiple organs. The genetic diversity of CHIKV, which caused recurring outbreaks in India, was studied. Blood samples were collected from suspected human cases of CHIKV infection in Chennai, Tamil Nadu and three Northern districts of Kerala in Southern India during the CHIKV outbreak in 2009. A partial E2 gene segment was amplified by RT-PCR. Among 119 samples 37 samples were positive for CHIKV by RT-PCR. Phylogenetic analysis revealed that the isolated sequences belonged to Indian Ocean Lineage (IOL) of ECSA genotype. The mutational analysis revealed the presence of substitutions such as S299N, T312M, A344T, S375T, V386G, W339R and S375P in the current study. In addition, a novel mutation V386G was observed in all the sequences. Two isolates found with unique substitutions W339R and S375P are reported. The structural analysis of the wild type and mutant proteins revealed that the structural changes are accompanied by modification in the intraprotein interactions.

Indexed as

Chikungunya viruspartial E2 geneRT-PCRselection pressuresubstitutions

Identifiers

PMID29785069
PMCPMC5953859
OpenAlexW2794765483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.