ArticleNature medicine2018
Targeting skeletal endothelium to ameliorate bone loss.
Abstract read
In one paragraph
Article in Nature medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed, 3 pooled it
12.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
228 citing papers in PubMed, 3 syntheses or guidelines pooled it, 355 citations in OpenAlex.
- Significance of Stem Cell-Derived Exosomes in Femoral Head Necrosis: A Systematic Review and Meta-Analysis of Preclinical Studies.Stem cell reviews and reports · 2026Pooled it
- Research progress in the pathogenesis of hormone-induced femoral head necrosis based on microvessels: a systematic review.Journal of orthopaedic surgery and research · 2024Pooled it
- Insights into the mechanism of vascular endothelial cells on bone biology.Bioscience reports · 2021Pooled it
- Growth plate cartilage-targeting nanoparticles for pharmacological treatment of hypochondroplasia.Bioactive materials · 2026Article
- Vascular-lymphatic dual circulation in bone health and disease: Mechanistic coupling and translational therapeutics.Journal of orthopaedic translation · 2026Review
- Identification and Potential Functions of MicroRNAs Involved in Freshwater Adaptation in Aquatic FireflyInsects · 2026Article
- Osteocyte-vascular Interactions in Bone Physiology and Pathology.Current osteoporosis reports · 2026Review
- Extracellular Vesicles as Immunomodulatory Mediators in Angiogenic-Osteogenic Coupling: Mechanistic Insights and Therapeutic Potential.Advanced healthcare materials · 2026Review
- Review
- Tissue Engineering for Massive Bone Defects: The Volumetric Scaling Problem and Strategies to Solve It.Bioengineering (Basel, Switzerland) · 2026Review
- Gli1⁺ cell aggregates promote type H vessel formation and orchestrate bone defect regeneration.Stem cell research & therapy · 2026Article
- Multifunctional Bioactive Scaffold Facilitating BMSCs-Driven Osteogenesis and Vascularization in Critical-Sized Bone Defect Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Constructing advanced electrospun nanofiber/hydrogel composite scaffolds loading with nano hydroxyapatite and puerarin for promoting osseointegration and osteanagenesis in a rat cranial defect model.Materials today. Bio · 2026Article
- Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy.Advanced healthcare materials · 2026Review
- A migrasome-based osteoinductive strategy: reprogramming the bone microenvironment for accelerated coupling of angiogenesis and osteogenesis.Journal of nanobiotechnology · 2026Article
- Sonic hedgehog reduces alveolar bone resorption by triggering the coupling of type H vessel formation and osteogenesis in a periodontitis model.BMC oral health · 2026Article
- Targeting coupling of type H-like vessels and cell fate transition to delay soft tissue aging.Nature communications · 2026Article
- A novel non-invasive approach monitoring skeletal stem cell function throughJournal of orthopaedic translation · 2026Article
- Crosstalk between bone and vasculature within bone.Fundamental research · 2026Review
- Neural regulation of bone: from central neural circuits to peripheral innervation of the skeletal stem cell niche.Bone research · 2026Review
168 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors at 7 institutions in 2 countries.
Ren XuDepartment of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA.ORCID http://orcid.org/0000-0001-6578-4553
Alisha YallowitzDepartment of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA.
An QinDepartment of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhuhao WuLaboratory of Brain Development and Repair, The Rockefeller University, New York, NY, USA.
Dong Yeon ShinDepartment of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA.
Jung-Min KimDivision of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Shawon DebnathDepartment of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA.
Gang JiResearch Division, Hospital for Special Surgery, New York, NY, USA.
Mathias P BostromResearch Division, Hospital for Special Surgery, New York, NY, USA.
Xu YangResearch Division, Hospital for Special Surgery, New York, NY, USA.
Chao ZhangInstitute for Computational Biomedicine, Cornell University, New York, NY, USA.
Han DongDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Harvard University Medical School, Boston, MA, USA.
Pouneh KermaniDivision of Regenerative Medicine, Department of Medicine, Ansary Stem Cell Institute, Cornell University, New York, NY, USA.
Sarfaraz LalaniDepartment of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA.
Na LiDepartment of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA.
Yifang LiuDepartment of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA.
Michael G PoulosDivision of Regenerative Medicine, Department of Medicine, Ansary Stem Cell Institute, Cornell University, New York, NY, USA.
Amanda WachDepartment of Biomechanics, Hospital for Special Surgery, New York, NY, USA.
Yi ZhangDepartment of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA.
Kazuki InoueArthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Annarita Di LorenzoDepartment of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA.
Baohong ZhaoArthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Jason M ButlerDivision of Regenerative Medicine, Department of Medicine, Ansary Stem Cell Institute, Cornell University, New York, NY, USA.
Jae-Hyuck ShimDivision of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-4947-3293
Laurie H GlimcherDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Harvard University Medical School, Boston, MA, USA. laurie_glimcher@dfci.harvard.edu.
Matthew B GreenblattDepartment of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA. mag3003@med.cornell.edu.
Cornell University · USHospital for Special Surgery · USBrigham and Women's Hospital · USUniversity of Massachusetts Chan Medical School · USHebei Medical University · CNRockefeller University · USShanghai Ninth People's Hospital · CN
Funding
Regulation of Osteoclastogenesis and Arthritic Bone Resorption by RBP-JR01AR071463 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI Baohong Zhao · 2017 to 2026
$4.0MEndothelial Sphingolipid Synthesis and Tissue Inflammatory ResponseR01HL126913 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DI LORENZO, ANNARITA · 2015 to 2023
$3.5MModulation of Bone Formation by SHN3DP5OD021351 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI GREENBLATT, MATTHEW BLAKE · 2015 to 2019
$2.1MMechanisms of inflammatory bone remodelingR01AR068970 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI ZHAO, BAOHONG · 2016 to 2021
$1.9MIdentification of novel regulators governing osteoclast-osteoblast couplingR01AR068983 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHIM, JAE-HYUCK · 2016 to 2020
$1.9M"Establishing Pathways for Endothelial Support of Bone Formation with SLIT3"R01AR075585 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GREENBLATT, MATTHEW BLAKE · 2020 to 2024
$1.8MCell SorterS10OD019986 · OD · HOSPITAL FOR SPECIAL SURGERY · PI LU, THERESA T. · 2015 to 2015
$600kNHLBI NIH HHS R01 HL126913NIAMS NIH HHS R01 AR068970NIAMS NIH HHS R01 AR068983NIAMS NIH HHS R01 AR071463NIAMS NIH HHS R01 AR075585NIH HHS DP5 OD021351NIH HHS S10 OD019986
Abstract
Recent studies have identified a specialized subset of CD31
Indexed as
AnimalsBone and BonesBone Marrow CellsBone ResorptionDisease Models, AnimalDNA-Binding ProteinsEndotheliumFracture HealingHumansMembrane ProteinsMice, Inbred BALB CMice, Inbred C57BLNeovascularization, PhysiologicNerve Tissue ProteinsOsteoblastsOsteogenesisDNA-Binding ProteinsEmcn protein, mouseMembrane ProteinsNerve Tissue ProteinsPlatelet Endothelial Cell Adhesion Molecule-1Receptors, ImmunologicRecombinant ProteinsRoundabout ProteinsSchnurri-3 protein, mouseSialoglycoproteinsSlit3 protein, mouse
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.