ArticleNature genetics2018
3' UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk.
Abstract read
In one paragraph
Article in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
109 citing papers in PubMed, 197 citations in OpenAlex.
- NUDT21 Drives T-Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- NUDT21-mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration.Nature communications · 2026Article
- AC005034.3/hsa-miR-126-5p/EIF3H axis: bioinformatics analysis, expression validation, and association with prognosis and immunosuppressive microenvironment in pancreatic adenocarcinoma.Frontiers in cell and developmental biology · 2026Article
- Androgen induces 3'UTR shortening of de novo lipogenesis genes by alternative polyadenylation in prostate cancer cells.Science China. Life sciences · 2025Article
- Molecular mechanism of nano-vitamin A-mediated regulation of intramuscular fat deposition involving noncoding RNAs in pigs.BMC genomics · 2025Article
- Transcriptome-wide association study of alternative polyadenylation identifies susceptibility genes in non-small cell lung cancer.Oncogene · 2025Article
- Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non-small Cell Lung Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.Cell discovery · 2025Article
- Characterization and molecular targeting of CFIm25 (NUDT21/CPSF5) mRNA using miRNAs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells.Cell reports · 2025Article
- Alternative polyadenylation shapes the molecular and clinical features of lung adenocarcinoma.Human molecular genetics · 2025Article
- Impact of rare non-coding variants on human diseases through alternative polyadenylation outliers.Nature communications · 2025Article
- Quantitative measures to assess the quality of cellular indexing of transcriptomes and epitopes by sequencing data.Frontiers in bioinformatics · 2025Article
- The roles and mechanisms of coding and noncoding RNA variations in cancer.Experimental & molecular medicine · 2024Review
- Coding, or non-coding, that is the question.Cell research · 2024Review
- Review
- Tiam1-mediated maladaptive plasticity underlying morphine tolerance and hyperalgesia.Brain : a journal of neurology · 2024Article
- Micropeptide AF127577.4-ORF hidden in a lncRNA diminishes glioblastoma cell proliferation via the modulation of ERK2/METTL3 interaction.Scientific reports · 2024Article
- RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation.Cell discovery · 2024Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Hyun Jung ParkDivision of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Ping JiDepartment of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Soyeon KimCenter for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Zheng XiaDivision of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Benjamin RodriguezDivision of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Lei LiDivision of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-3924-2544
Jianzhong SuDivision of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Kaifu ChenDivision of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Chioniso P MasamhaDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Butler University, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-2427-786X
David BaillatDepartment of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Camila R Fontes-GarfiasDepartment of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Ann-Bin ShyuDepartment of Biochemistry and Molecular Biology, University of Texas, McGovern Medical School, Houston, TX, USA.
Joel R NeilsonDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Eric J WagnerDepartment of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA. ejwagner@utmb.edu.
Wei LiDivision of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA. WL1@bcm.edu.ORCID http://orcid.org/0000-0001-9931-5990
Baylor College of Medicine · USThe University of Texas Medical Branch at Galveston · USThe University of Texas Health Science Center at Houston · USButler University · USUniversity of Pittsburgh · US
Funding
Systems Analysis of Epigenomic Architecture in Cancer ProgressionU54CA217297 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HUANG, TIM H.-M. · 2017 to 2021
$9.3MMessenger RNA Turnover in Mammalian CellsR01GM046454 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SHYU, ANN-BIN · 1991 to 2016
$7.1MComputational and Experimental Modeling of Alternative PolyadenylationR01CA193466 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LI, WEI · 2016 to 2025
$3.3MRegulation of Messenger RNA Turnover in Mammalian CellsR35GM127109 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SHYU, ANN-BIN · 2018 to 2022
$2.3MComputational and Experimental Modeling of Epigenetic DNA MethylationR01HG007538 · NHGRI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LI, WEI · 2014 to 2018
$1.9MIn Silico Screening of Alternative Polyadenylation Regulators in CancersK01LM012877 · NLM · OREGON HEALTH & SCIENCE UNIVERSITY · PI XIA, ZHENG · 2018 to 2020
$428kNCI NIH HHS R01 CA193466NCI NIH HHS U54 CA217297NHGRI NIH HHS R01 HG007538NIGMS NIH HHS R01 GM046454NIGMS NIH HHS R35 GM127109NLM NIH HHS K01 LM012877
Abstract
Widespread mRNA 3' UTR shortening through alternative polyadenylation
Indexed as
3' Untranslated RegionsGenes, Tumor SuppressorCell Line, TumorGene Expression Regulation, NeoplasticHeLa CellsHumansMCF-7 CellsMicroRNAsNeoplasmsProto-Oncogene MasProto-OncogenesRNARNA, Messenger3' Untranslated RegionsMAS1 protein, humanMicroRNAsProto-Oncogene MasRNARNA, Messenger
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.