SynthesisNature genetics2018
Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.
Registry-linked trialOpen access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05175651 (Prospective Electronic Polygenic Risk Study - Second Phase), which is not on this map. Cited by 176 papers, 11 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 11 pooled it
31.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Electronic Polygenic Risk Study - Second Phase
Who cites it
176 citing papers in PubMed, 11 syntheses or guidelines pooled it, 380 citations in OpenAlex.
- Evaluation of the Observational Associations and Shared Genetics Between Glaucoma With Depression and Anxiety.Investigative ophthalmology & visual science · 2024Pooled it
- Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation.Cell reports. Medicine · 2024Pooled it
- Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders.Human genetics · 2023Pooled it
- Glaucoma Genetic Risk Scores in the Million Veteran Program.Ophthalmology · 2022Pooled it
- High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.Investigative ophthalmology & visual science · 2022Pooled it
- Gene Set Enrichment Analsyes Identify Pathways Involved in Genetic Risk for Diabetic Retinopathy.American journal of ophthalmology · 2022Pooled it
- Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.Nature communications · 2021Pooled it
- A comprehensive map of disease networks and molecular drug discoveries for glaucoma.Scientific reports · 2020Pooled it
- Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia.Nature genetics · 2020Pooled it
- Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.Communications biology · 2019Pooled it
- The Association of Female Reproductive Factors with Glaucoma and Related Traits: A Systematic Review.Ophthalmology. GlaucomaPooled it
- Tie2 Activation via VE-PTP Inhibition With Razuprotafib as an Adjunct to Latanoprost in Patients With Open Angle Glaucoma or Ocular Hypertension.Translational vision science & technology · 2022Trial
- A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure.Investigative ophthalmology & visual science · 2020Trial
- VEGFA-Positive Macrophages Regulate Aqueous Humor Outflow in Aged Mice and Humans.bioRxiv : the preprint server for biology · 2026Article
- Mouse predation is dependent on a population of POU6F2-positive retinal ganglion cells.iScience · 2026Article
- Genome-Wide Association Study for Glucocorticoid-Induced Ocular Hypertension.Ophthalmology science · 2026Article
- Association of FunctionalInternational journal of molecular sciences · 2026Article
- Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular Meshwork.bioRxiv : the preprint server for biology · 2026Article
- A Primary Open-Angle Glaucoma Locus Near Transcription FactorOphthalmology science · 2026Article
- Transcending genome-wide association studies to create useful multi-omic views of glaucoma.Progress in retinal and eye research · 2026Review
116 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 7 institutions in 3 countries.
Anthony P KhawajaNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.ORCID http://orcid.org/0000-0001-6802-8585
Jessica N Cooke BaileyDepartment of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-4001-8702
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Mark SimcoeDepartment of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK.ORCID http://orcid.org/0000-0003-2432-0810
Robert P IgoDepartment of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Yeunjoo E SongDepartment of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Robert WojciechowskiJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Peng T KhawNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
Louis R PasqualeDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5835-3496
Jonathan L HainesDepartment of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-4351-4728
Paul J FosterNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.ORCID http://orcid.org/0000-0002-4755-177X
Janey L WiggsDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. janey_wiggs@meei.harvard.edu.ORCID http://orcid.org/0000-0003-1890-3278
Chris J HammondDepartment of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK. chris.hammond@kcl.ac.uk.ORCID http://orcid.org/0000-0002-3227-2620
Pirro G HysiDepartment of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK. pirro.hysi@kcl.ac.uk.ORCID http://orcid.org/0000-0001-5752-2510
UK Biobank Eye and Vision Consortium
NEIGHBORHOOD Consortium
Case Western Reserve University · USMoorfields Eye Hospital NHS Foundation Trust · GBSt Thomas' Hospital · GBMassachusetts Eye and Ear Infirmary · USUniversity of Cambridge · GBJohns Hopkins University · USNational University of Singapore · SG
Funding
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MUniversity of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9MInstitutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MA Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4MStructural dynamics of developing auditory circuitsP20RR015574 · NCRR · WEST VIRGINIA UNIVERSITY · PI SPIROU, GEORGE A · 2000 to 2009
$18.1MNovel Glaucoma Diagnostics for Structure and Function - Renewal - 1R01EY013178 · NEI · WILLS EYE HEALTH SYSTEM · PI Joel S Schuman · 2000 to 2026
$17.5MP30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Janey L Wiggs · 2002 to 2026
$15.1MSNP discoveryP01HL073042 · NHLBI · DUKE UNIVERSITY · PI NEVINS, JOSEPH R · 2002 to 2006
$13.5MUnifying Genetics Epidemiology of Macular DegenerationR01EY012118 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI AGARWAL, ANITA, HAINES, JONATHAN L · 2006 to 2015
$12.2MCancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5MMedical Research Council G1000143Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_12015/1Medical Research Council MR/N003284/1NCATS NIH HHS UL1 TR000427NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA131332NCI NIH HHS U01 CA049449NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NCRR NIH HHS P20 RR015574NEI NIH HHS P30 EY014104NEI NIH HHS R01 EY008208NEI NIH HHS R01 EY009580NEI NIH HHS R01 EY009847NEI NIH HHS R01 EY010886NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY011671NEI NIH HHS R01 EY012118NEI NIH HHS R01 EY013178NEI NIH HHS R01 EY013315NEI NIH HHS R01 EY015473NEI NIH HHS R01 EY015543NEI NIH HHS R01 EY015872NEI NIH HHS R01 EY018660NEI NIH HHS R01 EY019126NEI NIH HHS R01 EY022305NEI NIH HHS R03 EY015682NEI NIH HHS R56 EY011671NEI NIH HHS U10 EY012118NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004608NHGRI NIH HHS U01 HG004728NHGRI NIH HHS U01 HG006389NHLBI NIH HHS P01 HL073042NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL073389NHLBI NIH HHS R01 HL080467Wellcome Trust 094791
Abstract
Glaucoma is the leading cause of irreversible blindness globally
Indexed as
AdultAgedCohort StudiesFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGlaucoma, Open-AngleHumansIntraocular PressureMaleMiddle AgedPolymorphism, Single NucleotideRisk Factors
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT05175651ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.