Evidence map›Paper›PMID 29784996›Full record

ArticleNature materials2018

Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke.

Lina R Nih, Shiva Gojgini, S Thomas Carmichael, Tatiana Segura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 3 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 3 syntheses or guidelines pooled it, 335 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lina R NihDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, USA.
Shiva GojginiDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, USA.
S Thomas CarmichaelDepartment of Neurology David Geffen School of Medicine, University of California, Los Angeles, USA, CA. scarmichael@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-1169-9203
Tatiana SeguraDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, USA. tatiana.segura@duke.edu.ORCID http://orcid.org/0000-0003-1569-8686
University of California, Los Angeles · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
VEGF Ligand Presentation and Therapeutic AngiogenesisR01NS079691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEGURA, TATIANA · 2012 to 2024
$4.0M
NIDDK NIH HHS P30 DK041301NINDS NIH HHS R01 NS079691
6 · The paper itself

Abstract

Stroke is the primary cause of disability due to the brain's limited ability to regenerate damaged tissue. After stroke, an increased inflammatory and immune response coupled with severely limited angiogenesis and neuronal growth results in a stroke cavity devoid of normal brain tissue. In the adult, therapeutic angiogenic materials have been used to repair ischaemic tissues through the formation of vascular networks. However, whether a therapeutic angiogenic material can regenerate brain tissue and promote neural repair is poorly understood. Here we show that the delivery of an engineered immune-modulating angiogenic biomaterial directly to the stroke cavity promotes tissue formation de novo, and results in axonal networks along thee generated blood vessels. This regenerated tissue produces functional recovery through the established axonal networks. Thus, this biomaterials approach generates a vascularized network of regenerated functional neuronal connections within previously dead tissue and lays the groundwork for the use of angiogenic materials to repair other neurologically diseased tissues.

Indexed as

Biocompatible MaterialsNeovascularization, PhysiologicAnimalsBrainHeparinHumansNanoparticlesNeurogenesisRecovery of FunctionStrokeVascular Endothelial Growth Factor ABiocompatible MaterialsHeparinVascular Endothelial Growth Factor A

Identifiers

PMID29784996
PMCPMC6019573
OpenAlexW2803995469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.