Evidence map›Paper›PMID 29784975›Full record

ArticleNature microbiology2018

A unique cytoplasmic ATPase complex defines the Legionella pneumophila type IV secretion channel.

David Chetrit, Bo Hu, Peter J Christie, Craig R Roy, Jun Liu

Abstract read
In one paragraph

Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 100 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Type IV Secretion System Drives Lipid Mixing.bioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Molecular evolution and adaptations ofFrontiers in cellular and infection microbiology · 2026
    Review
  10. Review
  11. Article
  12. Conformational transitions enabling interkingdom transfer of effector multitudes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Review
  14. Article
  15. In situ structures of theProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Review
  17. OptimizedMicrobiology spectrum · 2025
    Article
  18. Article
  19. Article
  20. Journal of bacteriology · 2024
    Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

David Chetrit *Department of Microbial Pathogenesis, Microbial Sciences Institute and Boyer Center for Molecular Medicine, Yale School of Medicine, New Haven, CT, USA.
Bo Hu *Department of Microbiology and Molecular Genetics, Houston, TX, USA.
Peter J ChristieDepartment of Microbiology and Molecular Genetics, Houston, TX, USA.
Craig R RoyDepartment of Microbial Pathogenesis, Microbial Sciences Institute and Boyer Center for Molecular Medicine, Yale School of Medicine, New Haven, CT, USA. craig.roy@yale.edu.ORCID http://orcid.org/0000-0003-4490-440X
Jun LiuDepartment of Microbial Pathogenesis, Microbial Sciences Institute and Boyer Center for Molecular Medicine, Yale School of Medicine, New Haven, CT, USA. jliu@yale.edu.ORCID http://orcid.org/0000-0003-3108-6735
Baylor Genetics · USYale University · US

Funding

TRANSLOCATION OF DNA ACROSS THE AGROBACTERIUM ENVELOPER01GM048746 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHRISTIE, PETER J. · 1998 to 2018
$6.9M
Structure-Function Relationships in the Spirochetal Flagellar MotorR01AI087946 · NIAID · YALE UNIVERSITY · PI LIU, JUN · 2010 to 2025
$6.6M
Genetic Analysis of Legionella Phagosome TraffickingR37AI041699 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 2012 to 2021
$5.3M
Structural basis of signaling between bacterial chemoreceptors and flagellaR01GM107629 · NIGMS · YALE UNIVERSITY · PI LIU, JUN · 2014 to 2017
$1.5M
Functional and structural analysis of the Legionella pneumophila Dot/Icm apparatusR21AI130671 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 2018 to 2019
$461k
NIAID NIH HHS R01 AI087946NIAID NIH HHS R21 AI130671NIAID NIH HHS R37 AI041699NIGMS NIH HHS R01 GM048746NIGMS NIH HHS R01 GM107629
6 · The paper itself

Abstract

Type IV secretion systems (T4SSs) are complex machines used by bacteria to deliver protein and DNA complexes into target host cells

Indexed as

Adenosine TriphosphatasesAnimalsBacterial ProteinsCryoelectron MicroscopyCytoplasmGene Expression Regulation, BacterialLegionella pneumophilaMiceModels, MolecularProtein MultimerizationRAW 264.7 CellsType IV Secretion SystemsAdenosine TriphosphatasesBacterial ProteinsDotB protein, Legionella pneumophilaType IV Secretion Systems

Identifiers

PMID29784975
PMCPMC5970066
OpenAlexW2803225861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.