ArticleScientific reports2018
Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.
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Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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35citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Identification of 13 Novel Loci in a Genome-Wide Association Study on Taiwanese with Hepatocellular Carcinoma.International journal of molecular sciences · 2023Pooled it
- Evaluating a Polygenic Risk Score for Hepatocellular Carcinoma in Multiethnic Cirrhosis Patients in Texas.Cancer medicine · 2026Article
- Genetic Determinants of Infectious Diseases in the Qatari Population.Epidemiologia (Basel, Switzerland) · 2026Article
- Review
- HLA-DQB1*03:01 and risk of HBV-related HCC.Hepatology (Baltimore, Md.) · 2026Article
- APM-Related gene signature model to predict prognosis and immunotherapy response in hepatocellular carcinoma.Human genetics · 2025Article
- Human leukocyte antigen-G in hepatocellular carcinoma driven by chronic viral hepatitis or steatotic liver disease.Scientific reports · 2025Article
- Genome-wide functional integration identified MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma.Archives of toxicology · 2024Article
- Molecular Analysis of HLA Genes in Romanian Patients with Chronic Hepatitis B Virus Infection.Current issues in molecular biology · 2024Article
- A transcriptome-wide association study identified susceptibility genes for hepatocellular carcinoma in East Asia.Gastroenterology report · 2024Article
- Influence of HLA-A, -B, -DR Polymorphisms on the Severity of COVID-19: A Case-Control Study in the Iranian Population.Archives of Iranian medicine · 2023Article
- Prediction Model withInternational journal of molecular sciences · 2023Article
- Learning from the nexus of autoimmunity and cancer.Immunity · 2023Review
- NovelFrontiers in immunology · 2023Article
- Bw4 ligand and direct T-cell receptor binding induced selection on HLA A and B alleles.Frontiers in immunology · 2023Article
- Evolutionary Origins of Metabolic Reprogramming in Cancer.International journal of molecular sciences · 2022Review
- An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.Nature communications · 2022Article
- Genetic susceptibility to hepatocellular carcinoma in chromosome 22q13.31, findings of a genome-wide association study.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues.Cell reports · 2021Article
- Association analysis of KIR/HLA genotype with liver cirrhosis, hepatocellular carcinoma, and NUC freedom in chronic hepatitis B patients.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
40 authors at 18 institutions in 3 countries.
Hiromi SawaiDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. sawai@m.u-tokyo.ac.jp.
Nao NishidaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Seik-Soon KhorDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masao HondaDepartment of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Masaya SugiyamaGenome Medical Science Project, National Center for Global Health and Medicine, Ichikawa, Japan.
Natsumi BabaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kayoko YamadaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Norie SawadaEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Shoichiro TsuganeEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.ORCID 0000-0003-4105-2774
Kazuhiko KoikeDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yuji KondoDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hiroshi YatsuhashiClinical Research Center, National Nagasaki Medical Center, Nagasaki, Japan.
Shinya NagaokaClinical Research Center, National Nagasaki Medical Center, Nagasaki, Japan.
Akinobu TaketomiDepartment of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Moto FukaiDepartment of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Masayuki KurosakiDivision of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.
Namiki IzumiDivision of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.
Jong-Hon KangCenter for Gastroenterology, Teine Keijinkai Hospital, Sapporo, Japan.
Kazumoto MurataGenome Medical Science Project, National Center for Global Health and Medicine, Ichikawa, Japan.
Keisuke HinoDepartment of Hepatology and Pancreatology, Kawasaki Medical School, Kurashiki, Japan.
Sohji NishinaDepartment of Hepatology and Pancreatology, Kawasaki Medical School, Kurashiki, Japan.
Akihiro MatsumotoDepartment of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Eiji TanakaDepartment of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Naoya SakamotoDepartment of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
Koji OgawaDepartment of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
Kazuhide YamamotoDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Akihiro TamoriDepartment of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Osamu YokosukaDepartment of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Tatsuo KandaDepartment of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0002-9565-4669
Isao SakaidaGastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
Yoshito ItohMolecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yuichiro EguchiLiver center, Saga University Hospital, Saga, Japan.
Satoshi OedaLiver center, Saga University Hospital, Saga, Japan.
Satoshi MochidaDivision of Gastroenterology and Hepatology, Saitama Medical University, Saitama, Japan.
Man-Fung YuenDepartment of Medicine and State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, China.
Wai-Kay SetoDepartment of Medicine and State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, China.
Yong PoovorawanCenter of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Nawarat PosuwanCenter of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Masashi MizokamiGenome Medical Science Project, National Center for Global Health and Medicine, Ichikawa, Japan.
Katsushi TokunagaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPHokkaido University · JPNational Center for Global Health and Medicine · JPChiba University · JPChulalongkorn University · THKawasaki Medical School · JPMusashino Red Cross Hospital · JPNagasaki Medical Center · JPSaga University · JPShinshu University · JPUniversity of Hong Kong · HKKanazawa University · JPKyoto Prefectural University of Medicine · JPOkayama University · JPOsaka City University · JPSaitama Medical University · JPTeine Keijinkai Hospital · JPYamaguchi University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carrier individuals to identify new host genetic factors associated with HBV-derived HCC in Japanese and other East Asian populations. We identified 65 SNPs with P values < 10
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyPolymorphism, Single NucleotideCarcinoma, HepatocellularGenetic LociHepatitis B, ChronicHepatitis B virusHistocompatibility Antigens Class IHumansLiver NeoplasmsRisk FactorsHistocompatibility Antigens Class I
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.