ArticleNature communications2018
Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed.
- The Vertebrate Genomes Project Phase I: A global reference genome resource.bioRxiv : the preprint server for biology · 2026Article
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- Evolution of chromosomes and nuclear architectures of amniotes.Nature communications · 2025Article
- Genome Architecture and Speciation in Plants and Animals.Molecular ecology · 2025Review
- Epidemiology, Virology, and Control of Highly Pathogenic Avian Influenza in Kazakhstan.Pathogens (Basel, Switzerland) · 2025Review
- The complete genome of a songbird.bioRxiv : the preprint server for biology · 2025Article
- From Micro to Macro: Avian Chromosome Evolution is Dominated by Natural Selection.bioRxiv : the preprint server for biology · 2024Article
- De novo genome assemblies of two cryptodiran turtles with ZZ/ZW and XX/XY sex chromosomes provide insights into patterns of genome reshuffling and uncover novel 3D genome folding in amniotes.Genome research · 2024Article
- Reconstructing the ancestral gene pool to uncover the origins and genetic links of Hmong-Mien speakers.BMC biology · 2024Article
- Review
- Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs.Nature communications · 2024Article
- Puzzle Hi-C: An accurate scaffolding software.PloS one · 2024Article
- Article
- Chromosome-level genome assembly of Phrynocephalus forsythii using third-generation DNA sequencing and Hi-C analysis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2023Article
- Three amphioxus reference genomes reveal gene and chromosome evolution of chordates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Reconstruction of hundreds of reference ancestral genomes across the eukaryotic kingdom.Nature ecology & evolution · 2023Article
- Evolutionary analysis of a complete chicken genome.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dinosaurs: Comparative Cytogenomics of Their Reptile Cousins and Avian Descendants.Animals : an open access journal from MDPI · 2022Review
- Microchromosome BAC-FISH Reveals Different Patterns of Genome Organization in Three Charadriiformes Species.Animals : an open access journal from MDPI · 2022Article
- Observations on chromosome-specific sequencing for the construction of cross-species chromosome homology maps and its resolution of human:alpaca homology.Molecular cytogenetics · 2022Review
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Abstract
Genomic organisation of extinct lineages can be inferred from extant chromosome-level genome assemblies. Here, we apply bioinformatic and molecular cytogenetic approaches to determine the genomic structure of the diapsid common ancestor. We then infer the events that likely occurred along this lineage from theropod dinosaurs through to modern birds. Our results suggest that most elements of a typical 'avian-like' karyotype (40 chromosome pairs, including 30 microchromosomes) were in place before the divergence of turtles from birds ~255 mya. This genome organisation therefore predates the emergence of early dinosaurs and pterosaurs and the evolution of flight. Remaining largely unchanged interchromosomally through the dinosaur-theropod route that led to modern birds, intrachromosomal changes nonetheless reveal evolutionary breakpoint regions enriched for genes with ontology terms related to chromatin organisation and transcription. This genomic structure therefore appears highly stable yet contributes to a large degree of phenotypic diversity, as well as underpinning adaptive responses to major environmental disruptions via intrachromosomal repatterning.
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