ArticleScientific reports2018
Video-rate volumetric neuronal imaging using 3D targeted illumination.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- NIR-II squeezed light-field microscopy enables high-speed volumetric imaging of deep-tissue dynamicsbioRxiv : the preprint server for biology · 2026Article
- Methods, Trade-offs, and Opportunities in High-speed Optical Microscopy for Neural Voltage imaging.Nature photonics · 2026Article
- Deep-learning endomicroscope with large field-of-view and depth-of-field for real-time in vivo imaging of epithelial cancer hallmarks.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Widefield Targeted Illumination Microscopy Enables Optically-Sectioned, Motion-Resilient Imaging of Neuronal Fibers and Their Dynamics.Laser & photonics reviews · 2025Article
- High-speed voltage imaging of action potentials in molecular layer interneurons reveals sensory-driven synchrony that augments movement.Cell reports · 2025Article
- Advancing Multicolor Super-Resolution Volume Imaging: Illuminating Complex Cellular Dynamics.JACS Au · 2025Review
- Compressive streak microscopy for fast sampling of fluorescent reporters of neural activity.Neurophotonics · 2025Article
- Random Illumination Microscopy: faster, thicker, and aberration-insensitive.Light, science & applications · 2025Article
- Extended-depth of field random illumination microscopy, EDF-RIM, provides super-resolved projective imaging.Light, science & applications · 2024Article
- Neurophotonics beyond the surface: unmasking the brain's complexity exploiting optical scattering.Neurophotonics · 2024Article
- Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution.Nature biomedical engineering · 2024Article
- Targeted illumination confocal microscopy enables in vivo voltage imaging in thick tissue.Nature methods · 2024Article
- Large-scale deep tissue voltage imaging with targeted-illumination confocal microscopy.Nature methods · 2024Article
- DeepDOF-SE: affordable deep-learning microscopy platform for slide-free histology.Nature communications · 2024Article
- Neurophotonics beyond the Surface: Unmasking the Brain's Complexity Exploiting Optical Scattering.ArXiv · 2024Article
- Learning flat optics for extended depth of field microscopy imaging.Nanophotonics (Berlin, Germany) · 2023Article
- Optical-resolution photoacoustic microscopy with a needle-shaped beam.Nature photonics · 2023Article
- Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types.Science (New York, N.Y.) · 2022Article
- Article
- An adaptive microscope for the imaging of biological surfaces.Light, science & applications · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Fast volumetric microscopy is required to monitor large-scale neural ensembles with high spatio-temporal resolution. Widefield fluorescence microscopy can image large 2D fields of view at high resolution and speed while remaining simple and costeffective. A focal sweep add-on can further extend the capacity of widefield microscopy by enabling extended-depth-of-field (EDOF) imaging, but suffers from an inability to reject out-of-focus fluorescence background. Here, by using a digital micromirror device to target only in-focus sample features, we perform EDOF imaging with greatly enhanced contrast and signal-to-noise ratio, while reducing the light dosage delivered to the sample. Image quality is further improved by the application of a robust deconvolution algorithm. We demonstrate the advantages of our technique for in vivo calcium imaging in the mouse brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.