Evidence map›Paper›PMID 29784874›Full record

ArticleThe Journal of biological chemistry2018

Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model.

Natalie A Hager, Collin J Krasowski, Timothy D Mackie, Alexander R Kolb, Patrick G Needham, Andrew A Augustine, Alison Dempsey, Christopher Szent-Gyorgyi, Marcel P Bruchez, Daniel J Bain and 3 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. YeastbioRxiv : the preprint server for biology · 2025
    Article
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  9. Review
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  12. AMPK-Mediated Regulation of Alpha-Arrestins and Protein Trafficking.International journal of molecular sciences · 2019
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Natalie A HagerFrom the Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282.
Collin J KrasowskiFrom the Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282.
Timothy D Mackiethe Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Alexander R Kolbthe Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Patrick G Needhamthe Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Andrew A Augustinethe Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Alison Dempseythe Molecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
Christopher Szent-Gyorgyithe Molecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
Marcel P Bruchezthe Molecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
Daniel J Bainthe Department of Geology and Environmental Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, and.
Adam V Kwiatkowskithe Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261.
Allyson F O'DonnellFrom the Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, odonne15@duq.edu.ORCID 0000-0003-0966-288X
Jeffrey L Brodskythe Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, jbrodsky@pitt.edu.
University of Pittsburgh · USDuquesne University · USImaging Center · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Fluorescent Biosensors for Networks and PathwaysU54GM103529 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI WAGGONER, ALAN S. · 2012 to 2013
$6.3M
Alpha-catenin function in cardiomyocyte adhesion and cytoskeletal organizationR01HL127711 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KWIATKOWSKI, ADAM VINCENT · 2016 to 2024
$3.5M
ER Associated Degradation of Membrane Proteins in YeastR01GM075061 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRODSKY, JEFFREY L. · 2006 to 2019
$3.2M
NHLBI NIH HHS R01 HL127711NIDDK NIH HHS P30 DK079307NIGMS NIH HHS R01 GM075061NIGMS NIH HHS U54 GM103529
6 · The paper itself

Abstract

Protein composition at the plasma membrane is tightly regulated, with rapid protein internalization and selective targeting to the cell surface occurring in response to environmental changes. For example, ion channels are dynamically relocalized to or from the plasma membrane in response to physiological alterations, allowing cells and organisms to maintain osmotic and salt homeostasis. To identify additional factors that regulate the selective trafficking of a specific ion channel, we used a yeast model for a mammalian potassium channel, the K

Indexed as

Models, BiologicalArrestinCell MembraneEndocytosisPotassiumPotassium Channels, Inwardly RectifyingProtein TransportSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsArrestinKir2.1 channelPotassiumPotassium Channels, Inwardly RectifyingSaccharomyces cerevisiae Proteinsarrestincalcineurinendocytosisinward rectifying channelprotein adaptorprotein quality controlprotein trafficking (Golgi)Saccharomyces cerevisiaeubiquitin ligasevacuoleyeast

Identifiers

PMID29784874
PMCPMC6052216
OpenAlexW2804836695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.