Evidence map›Paper›PMID 29784864›Full record

ArticleInfection and immunity2018

Group IIA-Secreted Phospholipase A

Fernanda L Paganelli, Helen L Leavis, Samantha He, Nina M van Sorge, Christine Payré, Gérard Lambeau, Rob J L Willems, Suzan H M Rooijakkers

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  5. Role of theApplied and environmental microbiology · 2022
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  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Fernanda L PaganelliDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands f.paganelli@umcutrecht.nl.
Helen L LeavisDepartment of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Samantha HeDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Nina M van SorgeDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-2695-5863
Christine PayréUniversité Côte d'Azur, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.
Gérard LambeauUniversité Côte d'Azur, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.
Rob J L WillemsDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Suzan H M RooijakkersDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Utrecht University · NLCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human innate immunity employs cellular and humoral mechanisms to facilitate rapid killing of invading bacteria. The direct killing of bacteria by human serum is attributed mainly to the activity of the complement system, which forms pores in Gram-negative bacteria. Although Gram-positive bacteria are considered resistant to killing by serum, we uncover here that normal human serum effectively kills

Indexed as

Anti-Bacterial AgentsCell MembraneEnterococcus faeciumHealthy VolunteersHumansMicrobial ViabilityPermeabilityPhospholipases A2SerumAnti-Bacterial AgentsPhospholipases A2commensalsEnterococcus faeciumgroup IIA secreted phospholipase A2innate immune systempathogens

Identifiers

PMID29784864
PMCPMC6056852
OpenAlexW2949143457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.