Evidence map›Paper›PMID 29784863›Full record

ArticleInfection and immunity2018

The Glycosylphosphatidylinositol Transamidase Complex Subunit PbGPI16 of Plasmodium berghei Is Important for Inducing Experimental Cerebral Malaria.

Qingyang Liu, Yan Zhao, Li Zheng, Xiaotong Zhu, Liwang Cui, Yaming Cao

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. mBio · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Unveiling the Sugary Secrets ofFrontiers in microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Qingyang LiuDepartment of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.
Yan ZhaoDepartment of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.
Li ZhengDepartment of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.
Xiaotong ZhuDepartment of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.
Liwang CuiDepartment of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China luc2@psu.edu ymcao@cmu.edu.cn.ORCID https://orcid.org/0000-0002-8338-1974
Yaming CaoDepartment of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China luc2@psu.edu ymcao@cmu.edu.cn.
China Medical University · CNPennsylvania State University · US

Funding

Puf-Mediated Translation Control in PlasmodiumR01AI104946 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI CUI, LIWANG · 2014 to 2017
$1.5M
Transmission blocking vaccine study in Plasmodium vivaxR01AI099611 · NIAID · CHINA MEDICAL UNIVERSITY · PI CAO, YAMING · 2012 to 2016
$648k
NIAID NIH HHS R01 AI099611NIAID NIH HHS R01 AI104946
6 · The paper itself

Abstract

In animal models of experimental cerebral malaria (ECM), the glycosylphosphatidylinositols (GPIs) and GPI anchors are the major factors that induce nuclear factor kappa B (NF-κB) activation and proinflammatory responses, which contribute to malaria pathogenesis. GPIs and GPI anchors are transported to the cell surface via a process called GPI transamidation, which involves the GPI transamidase (GPI-T) complex. In this study, we showed that GPI16, one of the GPI-T subunits, is highly conserved among

Indexed as

AminoacyltransferasesAnimalsBrainCell MembraneDisease Models, AnimalFemaleGene Knockout TechniquesGlycosylphosphatidylinositolsMalaria, CerebralMembrane ProteinsMerozoitesMice, Inbred C57BLNF-kappa BPlasmodium bergheiProtozoan ProteinsSurvival AnalysisAminoacyltransferasesGlycosylphosphatidylinositolsMembrane ProteinsNF-kappa BProtozoan ProteinstransamidasesVirulence Factorscerebral malariaGPI-TNF-κBPlasmodium berghei ANKA

Identifiers

PMID29784863
PMCPMC6056855
OpenAlexW2804298133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.