Evidence map›Paper›PMID 29784843›Full record

ArticleAntimicrobial agents and chemotherapy2018

High Dose and Delayed Treatment with Bile Acids Ineffective in RML Prion-Infected Mice.

Grant Norman, Jody Campeau, Valerie L Sim

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Bile Acid Signaling in Neurodegenerative and Neurological Disorders.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Grant NormanCentre for Prions & Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
Jody CampeauCentre for Prions & Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
Valerie L SimCentre for Prions & Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada vsim@ualberta.ca.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prion diseases are a group of neurodegenerative diseases associated with the misfolding of the cellular prion protein (PrP

Indexed as

AnimalsAnti-Infective AgentsDisease Models, AnimalDrug Administration ScheduleFemaleMaleMicePrion DiseasesPrPSc ProteinsSurvival AnalysisTaurochenodeoxycholic AcidTime-to-TreatmentTreatment FailureUrsodeoxycholic AcidAnti-Infective AgentsPrPSc ProteinsTaurochenodeoxycholic AcidUrsodeoxycholic Acidursodoxicoltaurinebile acidin vivoprion diseaseRMLtherapyTUDCAUDCA

Identifiers

PMID29784843
PMCPMC6105847
OpenAlexW2803103630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.