ArticleProceedings of the National Academy of Sciences of the United States of America2018
Biological species in the viral world.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 93 citations in OpenAlex.
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- The Biology of Nucleus-Forming Jumbo Phages.Annual review of genetics · 2025Review
- Virocell resource manipulation under nutrient limitation.mSystems · 2025Article
- Genomic divergence across the tree of life.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploration of the genetic landscape of bacterial dsDNA viruses reveals an ANI gap amid extensive mosaicism.mSystems · 2025Article
- Phylogeny and species diversity ofMycology · 2025Article
- Are Viruses Taxonomic Units? A Protein Domain and Loop-Centric Phylogenomic Assessment.Viruses · 2024Review
- Infant gut DNA bacteriophage strain persistence during the first 3 years of life.Cell host & microbe · 2024Article
- Genome-wide support for incipient Tula hantavirus species within a single rodent host lineage.Virus evolution · 2024Article
- Bacteriophage Taxonomy: A Continually Evolving Discipline.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Genomic analysis of hyperparasitic viruses associated with entomopoxviruses.Virus evolution · 2024Article
- Enumerating soil biodiversity.Proceedings of the National Academy of Sciences of the United States of America · 2023Review
- Metagenomic analysis reveals unexplored diversity of archaeal virome in the human gut.Nature communications · 2022Article
- A Novel Inovirus Reprograms Metabolism and Motility of MarineMicrobiology spectrum · 2022Article
- Fecal Microbiota Transplantation and Other Gut Microbiota Manipulation Strategies.Microorganisms · 2022Review
- Recombination Events in Putative Tail Fibre Gene inViruses · 2022Article
- Development and Validation of a Bioinformatic Workflow for the Rapid Detection of Viruses in Biosecurity.Viruses · 2022Article
- Epidemiology of a major honey bee pathogen, deformed wing virus: potential worldwide replacement of genotype A by genotype B.International journal for parasitology. Parasites and wildlife · 2022Article
- Species divergence in gut-restricted bacteria of social bees.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Due to their dependence on cellular organisms for metabolism and replication, viruses are typically named and assigned to species according to their genome structure and the original host that they infect. But because viruses often infect multiple hosts and the numbers of distinct lineages within a host can be vast, their delineation into species is often dictated by arbitrary sequence thresholds, which are highly inconsistent across lineages. Here we apply an approach to determine the boundaries of viral species based on the detection of gene flow within populations, thereby defining viral species according to the biological species concept (BSC). Despite the potential for gene transfer between highly divergent genomes, viruses, like the cellular organisms they infect, assort into reproductively isolated groups and can be organized into biological species. This approach revealed that BSC-defined viral species are often congruent with the taxonomic partitioning based on shared gene contents and host tropism, and that bacteriophages can similarly be classified in biological species. These results open the possibility to use a single, universal definition of species that is applicable across cellular and acellular lifeforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.