Evidence map›Paper›PMID 29784816›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Encephalitis is mediated by ROP18 of

Ran An, Yuewen Tang, Lijian Chen, Haijian Cai, De-Hua Lai, Kang Liu, Lijuan Wan, Linli Gong, Li Yu, Qingli Luo and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pathogens (Basel, Switzerland) · 2026
    Pooled it
  2. Virulence · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Toxoplasma-host endoplasmic reticulum interaction: HowCurrent research in microbial sciences · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. From the immune system to mood disorders especially induced byFrontiers in cellular and infection microbiology · 2023
    Review
  11. Article
  12. The determinants regulatingFrontiers in microbiology · 2022
    Review
  13. Article
  14. Secreted Effectors Modulating Immune Responses toLife (Basel, Switzerland) · 2021
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Ran AnDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, People's Republic of China.
Yuewen TangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, People's Republic of China.
Lijian ChenDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, People's Republic of China.
Haijian CaiDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, People's Republic of China.
De-Hua LaiCenter for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China.ORCID 0000-0002-4709-1507
Kang LiuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, People's Republic of China.
Lijuan WanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, People's Republic of China.
Linli GongDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, People's Republic of China.
Li YuThe Key Laboratory of Pathogen Biology of Anhui Province, Anhui Medical University, Hefei 230032, People's Republic of China.
Qingli LuoThe Key Laboratory of Pathogen Biology of Anhui Province, Anhui Medical University, Hefei 230032, People's Republic of China.
Jilong ShenThe Key Laboratory of Pathogen Biology of Anhui Province, Anhui Medical University, Hefei 230032, People's Republic of China; shenjilong53@126.com lsslzr@mail.sysu.edu.cn fjayala@uci.edu dujane@163.com.ORCID 0000-0002-4755-3687
Zhao-Rong LunCenter for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China; shenjilong53@126.com lsslzr@mail.sysu.edu.cn fjayala@uci.edu dujane@163.com.
Francisco J AyalaDepartment of Ecology and Evolutionary Biology, Ayala School of Biological Sciences, University of California, Irvine, CA 92697 shenjilong53@126.com lsslzr@mail.sysu.edu.cn fjayala@uci.edu dujane@163.com.
Jian DuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, People's Republic of China; shenjilong53@126.com lsslzr@mail.sysu.edu.cn fjayala@uci.edu dujane@163.com.
Anhui Medical University · CNSun Yat-sen University · CNUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neurotropic parasite

Indexed as

Acquired Immunodeficiency SyndromeAnimalsApoptosisEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressFemaleHIV-1Host-Parasite InteractionsInfectious EncephalitisMiceMice, Inbred BALB CNerve Tissue ProteinsPhosphorylationProtein Serine-Threonine KinasesProtozoan ProteinsToxoplasmaEndoplasmic Reticulum Chaperone BiPHSPA5 protein, humanHspa5 protein, mouseNerve Tissue ProteinsProtein Serine-Threonine KinasesProtozoan ProteinsROP18 protein, Toxoplasma gondiiRtn1 protein, mouseER stressneural apoptosisphosphorylationROP18RTN1-C

Identifiers

PMID29784816
PMCPMC6003310
OpenAlexW2804245279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.