ArticleProceedings of the National Academy of Sciences of the United States of America2018
Chronic sleep curtailment, even without extended (>16-h) wakefulness, degrades human vigilance performance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Effect of sleep loss on pain-New conceptual and mechanistic avenues.Frontiers in neuroscience · 2022Pooled it
- Impact of chronic sleep restriction on sleep continuity, sleep structure, and neurobehavioral performance.Sleep · 2022Trial
- Chronic Circadian Disruption and Sleep Restriction Influence Subjective Hunger, Appetite, and Food Preference.Nutrients · 2022Trial
- Chronic sleep restriction greatly magnifies performance decrements immediately after awakening.Sleep · 2019Trial
- Effects of circadian misalignment on cognition in chronic shift workers.Scientific reports · 2019Trial
- Article
- Relationships between light exposure and aspects of cognitive function in everyday life.Communications psychology · 2025Article
- Deep sleep homeostatic response to naturalistic sleep loss.PLOS digital health · 2025Article
- Adding Insult to Injury: The Impact of Musculoskeletal Pain on Fishermen's Sleep Patterns.Journal of agromedicine · 2025Article
- Registry and survey of circadian rhythm sleep-wake disorder patients.Sleep medicine: X · 2024Article
- Re-Evaluating Recommended Optimal Sleep Duration: A Perspective on Sleep Literacy.Children (Basel, Switzerland) · 2024Review
- Review
- Predicting neurobehavioral performance of resident physicians in a Randomized Order Safety Trial Evaluating Resident-Physician Schedules (ROSTERS).Sleep health · 2024Article
- Associations between light exposure and sleep timing and sleepiness while awake in a sample of UK adults in everyday life.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Uncovering circadian rhythms in metabolic longitudinal data: A Bayesian latent class modeling approach.Statistics in medicine · 2023Article
- Desynchronizing the sleep---wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period.Nature protocols · 2023Review
- Effects of red light on sleep and mood in healthy subjects and individuals with insomnia disorder.Frontiers in psychiatry · 2023Article
- Effects of dynamic lighting on circadian phase, self-reported sleep and performance during a 45-day space analog mission with chronic variable sleep deficiency.Journal of pineal research · 2022Article
- Sleep-wake disorder: A silent health crisis in USA.Annals of medicine and surgery (2012) · 2022Article
- Time to learn: The role of the molecular circadian clock in learning and memory.Neurobiology of learning and memory · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Millions of individuals routinely remain awake for more than 18 h daily, which causes performance decrements. It is unknown if these functional impairments are the result of that extended wakefulness or from the associated shortened sleep durations. We therefore examined changes in objective reaction time performance and subjective alertness in a 32-d inpatient protocol in which participants were scheduled to wakefulness durations below 16 h while on a 20-h "day," with randomization into standard sleep:wake ratio (1:2) or chronic sleep restriction (CSR) ratio (1:3.3) conditions. This protocol allowed determination of the contribution of sleep deficiency independent of extended wakefulness, since individual episodes of wakefulness in the CSR condition were only 15.33 h in duration (less than the usual 16 h of wakefulness in a 24-h day) and sleep episodes were 4.67 h in duration each cycle. We found that chronic short sleep duration, even without extended wakefulness, doubled neurobehavioral reaction time performance and increased lapses of attention fivefold, yet did not uniformly decrease self-reported alertness. Further, these impairments in neurobehavioral performance were worsened during the circadian night and were not recovered during the circadian day, indicating that the deleterious effect from the homeostatic buildup of CSR is expressed even during the circadian promotion of daytime arousal. These findings reveal a fundamental aspect of human biology: Chronic insufficient sleep duration equivalent to 5.6 h of sleep opportunity per 24 h impairs neurobehavioral performance and self-assessment of alertness, even without extended wakefulness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.