Evidence map›Paper›PMID 29784808›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Hamartin regulates cessation of mouse nephrogenesis independently of Mtor.

Oded Volovelsky, Thi Nguyen, Alison E Jarmas, Alexander N Combes, Sean B Wilson, Melissa H Little, David P Witte, Eric W Brunskill, Raphael Kopan

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 58 citations in OpenAlex.

  1. Epigenetic regulation of kidney development.Nature reviews. Nephrology · 2026
    Review
  2. Article
  3. Article
  4. Testosterone Exposure During Fetal Masculinization Programming Window Determines the Kidney Size in Adult Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  5. A knock inbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Dicer-Mediated mTORC1 Signaling and Parathyroid Gland Integrity and Function.Journal of the American Society of Nephrology : JASN · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. The widely usedbioRxiv : the preprint server for biology · 2023
    Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Oded VolovelskyDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Thi NguyenDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Alison E JarmasDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Alexander N CombesMurdoch Children's Research Institute, Parkville, Melbourne, VIC 3052, Australia.
Sean B WilsonMurdoch Children's Research Institute, Parkville, Melbourne, VIC 3052, Australia.
Melissa H LittleMurdoch Children's Research Institute, Parkville, Melbourne, VIC 3052, Australia.
David P WitteDivision of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Eric W BrunskillDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Raphael KopanDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229; rafi.kopan@gmail.com.ORCID 0000-0002-0350-2730
Cincinnati Children's Hospital Medical Center · USThe University of Melbourne · AUMurdoch Children's Research Institute · AU

Funding

The Mechanism Regulating Renal Progenitor AgingR01DK106225 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI KOPAN, RAPHAEL · 2016 to 2020
$2.3M
Generating kidney organoids and mature renal cell types via directed iPSC differentiationUH3DK107344 · NIDDK · MURDOCH CHILDREN'S RESEARCH INSTITUTE · PI LITTLE, MELISSA HELEN · 2017 to 2019
$1.0M
NIDDK NIH HHS R01 DK106225NIDDK NIH HHS UH3 DK107344
6 · The paper itself

Abstract

Nephrogenesis concludes by the 36th week of gestation in humans and by the third day of postnatal life in mice. Extending the nephrogenic period may reduce the onset of adult renal and cardiovascular disease associated with low nephron numbers. We conditionally deleted either

Indexed as

NephronsAnimalsFemaleMaleMiceMice, TransgenicOrganogenesisTOR Serine-Threonine KinasesTuberous Sclerosis Complex 1 ProteinTumor Suppressor ProteinsmTOR protein, mouseTOR Serine-Threonine KinasesTSC1 protein, humanTsc1 protein, mouseTuberous Sclerosis Complex 1 ProteinTumor Suppressor Proteinskidney developmentmetanephric mesenchymeMtornephron progenitor cellsTsc1

Identifiers

PMID29784808
PMCPMC6003359
OpenAlexW2804050098

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.