ArticleProceedings of the National Academy of Sciences of the United States of America2018
Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
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- Nanoscale Biodegradable Printing for Designed Tuneability of Vaccine Delivery Kinetics.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Linking vaccine adjuvant mechanisms of action to function.Science immunology · 2025Review
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- Advancements in nanoscale delivery systems: optimizing intermolecular interactions for superior drug encapsulation and precision release.Drug delivery and translational research · 2025Review
- Demonstration of Tunable Control over a Delayed-Release Vaccine Using Atomic Layer Deposition.Vaccines · 2024Article
- Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems.Advanced drug delivery reviews · 2023Review
- A Scalable Platform for Fabricating Biodegradable Microparticles with Pulsatile Drug Release.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Recent advancements in single dose slow-release devices for prophylactic vaccines.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2023Review
- Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication.Human vaccines & immunotherapeutics · 2022Review
- Designing spatial and temporal control of vaccine responses.Nature reviews. Materials · 2022Review
- Transdermal microneedles for the programmable burst release of multiple vaccine payloads.Nature biomedical engineering · 2021Article
- Decisive Conditions for Strategic Vaccination against SARS-CoV-2.medRxiv : the preprint server for health sciences · 2021Article
- Microarray patches enable the development of skin-targeted vaccines against COVID-19.Advanced drug delivery reviews · 2021Review
- Engineered drug delivery devices to address Global Health challenges.Journal of controlled release : official journal of the Controlled Release Society · 2021Review
- Engineering Antiviral Vaccines.ACS nano · 2020Review
- Nanoengineered Light-Activatable Polybubbles for On-Demand Therapeutic Delivery.Advanced functional materials · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccination in the developing world is hampered by limited patient access, which prevents individuals from receiving the multiple injections necessary for protective immunity. Here, we developed an injectable microparticle formulation of the inactivated polio vaccine (IPV) that releases multiple pulses of stable antigen over time. To accomplish this, we established an IPV stabilization strategy using cationic polymers for pH modulation to enhance traditional small-molecule-based stabilization methods. We investigated the mechanism of this strategy and showed that it was broadly applicable to all three antigens in IPV. Our lead formulations released two bursts of IPV 1 month apart, mimicking a typical vaccination schedule in the developing world. One injection of the controlled-release formulations elicited a similar or better neutralizing response in rats, considered the correlate of protection in humans, than multiple injections of liquid vaccine. This single-administration vaccine strategy has the potential to improve vaccine coverage in the developing world.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.