ReviewDisease models & mechanisms2018
A guide to using functional magnetic resonance imaging to study Alzheimer's disease in animal models.
Review in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
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- Assessing and projecting the global impacts of Alzheimer's disease.Frontiers in public health · 2024Article
- Natural Corynanthe-Type Cholinesterase Inhibitors from MalaysianMetabolites · 2023Article
- Early memory deficits and extensive brain network disorganization in theAging brain · 2022Article
- Male and Female C57BL/6 Mice Respond Differently to Awake Magnetic Resonance Imaging Habituation.Frontiers in neuroscience · 2022Article
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- Analysis of Age-Related White Matter Microstructures Based on Diffusion Tensor Imaging.Frontiers in aging neuroscience · 2021Article
- Structural and Functional Hippocampal Correlations in Environmental Enrichment During the Adolescent to Adulthood Transition in Mice.Frontiers in systems neuroscience · 2021Article
- An open database of resting-state fMRI in awake rats.NeuroImage · 2020Article
- Hyper BOLD Activation in Dorsal Raphe Nucleus of APP/PS1 Alzheimer's Disease Mouse during Reward-Oriented Drinking Test under Thirsty Conditions.Scientific reports · 2020Article
- Network Pharmacology-Based and Experimental Identification of the Effects of Quercetin on Alzheimer's Disease.Frontiers in aging neuroscience · 2020Article
- Disease modelling in human organoids.Disease models & mechanisms · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Alzheimer's disease is a leading healthcare challenge facing our society today. Functional magnetic resonance imaging (fMRI) of the brain has played an important role in our efforts to understand how Alzheimer's disease alters brain function. Using fMRI in animal models of Alzheimer's disease has the potential to provide us with a more comprehensive understanding of the observations made in human clinical fMRI studies. However, using fMRI in animal models of Alzheimer's disease presents some unique challenges. Here, we highlight some of these challenges and discuss potential solutions for researchers interested in performing fMRI in animal models. First, we briefly summarize our current understanding of Alzheimer's disease from a mechanistic standpoint. We then overview the wide array of animal models available for studying this disease and how to choose the most appropriate model to study, depending on which aspects of the condition researchers seek to investigate. Finally, we discuss the contributions of fMRI to our understanding of Alzheimer's disease and the issues to consider when designing fMRI studies for animal models, such as differences in brain activity based on anesthetic choice and ways to interrogate more specific questions in rodents beyond those that can be addressed in humans. The goal of this article is to provide information on the utility of fMRI, and approaches to consider when using fMRI, for studies of Alzheimer's disease in animal models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.