Evidence map›Paper›PMID 29784640›Full record

ArticleBlood2018

Hypoxia downregulates protein S expression.

Vijaya S Pilli, Arani Datta, Sadaf Afreen, Donna Catalano, Gyongyi Szabo, Rinku Majumder

Abstract readLetter
In one paragraph

Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. High IntratumoralInternational journal of molecular sciences · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Disseminated intravascular coagulation.Journal of intensive care · 2025
    Review
  9. Review
  10. Article
  11. Pancreatic Cancer and Venous Thromboembolism.International journal of molecular sciences · 2024
    Review
  12. Review
  13. Article
  14. Article
  15. Association between PaOInternal and emergency medicine · 2023
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Vijaya S PilliDepartment of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, LA; and.
Arani DattaDepartment of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, LA; and.ORCID 0000-0002-2459-5964
Sadaf AfreenDepartment of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, LA; and.
Donna CatalanoDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA.
Gyongyi SzaboDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA.
Rinku MajumderDepartment of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, LA; and.ORCID 0000-0002-1727-7220

Funding

A NOVEL REGULATORY ROLE OF PROTEIN S IN BLOOD COAGULATIONR01HL118557 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAJUMDER, RINKU · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL118557
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsDown-RegulationHep G2 CellsHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitLiverMiceMice, KnockoutProtein SThrombosisHIF1A protein, humanHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitProtein S

Identifiers

PMID29784640
PMCPMC6071559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.