Evidence map›Paper›PMID 29784588›Full record

ArticleBrain stimulation

Brain stimulation patterns emulating endogenous thalamocortical input to parvalbumin-expressing interneurons reduce nociception in mice.

Yeowool Huh, Dahee Jung, Taeyoon Seo, Sukkyu Sun, Su Hyun Kim, Hyewhon Rhim, Sooyoung Chung, Chong-Hyun Kim, Youngwoo Kwon, Marom Bikson and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Personalizing neuromodulation.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Yeowool HuhTranslational Brain Research Center, Catholic Kwandong University International St. Mary's Hospital, Incheon, South Korea; Dept. of Medical Science, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, South Korea.
Dahee JungTranslational Brain Research Center, Catholic Kwandong University International St. Mary's Hospital, Incheon, South Korea; Dept. of Medical Science, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, South Korea; Department of Neuroscience, University of Science and Technology, Daejeon, South Korea.
Taeyoon SeoDepartment of Electrical and Computer Engineering, Seoul National University, Seoul, South Korea.
Sukkyu SunDepartment of Electrical and Computer Engineering, Seoul National University, Seoul, South Korea.
Su Hyun KimDepartment of Neuroscience, University of Science and Technology, Daejeon, South Korea; Center for Neuroscience, Korea Institute of Science and Technology, Seoul, South Korea.
Hyewhon RhimCenter for Neuroscience, Korea Institute of Science and Technology, Seoul, South Korea.
Sooyoung ChungDepartment of Neuroscience, University of Science and Technology, Daejeon, South Korea; Center for Neuroscience, Korea Institute of Science and Technology, Seoul, South Korea.
Chong-Hyun KimDepartment of Neuroscience, University of Science and Technology, Daejeon, South Korea; Center for Neuroscience, Korea Institute of Science and Technology, Seoul, South Korea.
Youngwoo KwonDepartment of Electrical and Computer Engineering, Seoul National University, Seoul, South Korea.
Marom BiksonDepartment of Biomedical Engineering, The City College of the City University of New York, NY, USA.
Yong-An ChungDepartment of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Jeansok J KimDepartment of Psychology, University of Washington, Seattle, WA, USA.
Jeiwon ChoTranslational Brain Research Center, Catholic Kwandong University International St. Mary's Hospital, Incheon, South Korea; Dept. of Medical Science, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, South Korea. Electronic address: jeiwon@cku.ac.kr.
Korea Institute of Science and Technology · KRCatholic Kwandong University International St. Mary's Hospital · KRSeoul National University · KRCity College of New York · USThe Catholic University of Korea Incheon St. Mary's Hospital · KRUniversity of Washington · US

Funding

Fear and Natural Risky Decisions in RatsR01MH099073 · NIMH · UNIVERSITY OF WASHINGTON · PI KIM, JEANSOK JOHN · 2013 to 2022
$3.9M
Neurocognitive Effects of StressR01MH064457 · NIMH · YALE UNIVERSITY · PI KIM, JEANSOK JOHN · 2002 to 2012
$2.6M
NIMH NIH HHS R01 MH064457NIMH NIH HHS R01 MH099073
6 · The paper itself

Abstract

backgroundThe bursting pattern of thalamocortical (TC) pathway dampens nociception. Whether brain stimulation mimicking endogenous patterns can engage similar sensory gating processes in the cortex and reduce nociceptive behaviors remains uninvestigated.

objectiveWe investigated the role of cortical parvalbumin expressing (PV) interneurons within the TC circuit in gating nociception and their selective response to TC burst patterns. We then tested if transcranial magnetic stimulation (TMS) patterned on endogenous nociceptive TC bursting modulate nociceptive behaviors.

methodsThe switching of TC neurons between tonic (single spike) and burst (high frequency spikes) firing modes may be a critical component in modulating nociceptive signals. Deep brain electrical stimulation of TC neurons and immunohistochemistry were used to examine the differential influence of each firing mode on cortical PV interneuron activity. Optogenetic stimulation of cortical PV interneurons assessed a direct role in nociceptive modulation. A new TMS protocol mimicking thalamic burst firing patterns, contrasted with conventional continuous and intermittent theta burst protocols, tested if TMS patterned on endogenous TC activity reduces nociceptive behaviors in mice.

resultsImmunohistochemical evidence confirmed that burst, but not tonic, deep brain stimulation of TC neurons increased the activity of PV interneurons in the cortex. Both optogenetic activation of PV interneurons and TMS protocol mimicking thalamic burst reduced nociceptive behaviors.

conclusionsOur findings suggest that burst firing of TC neurons recruits PV interneurons in the cortex to reduce nociceptive behaviors and that neuromodulation mimicking thalamic burst firing may be useful for modulating nociception.

Indexed as

NociceptionAnimalsInterneuronsMaleMiceParvalbuminsSensory GatingThalamusTranscranial Magnetic StimulationParvalbuminsBioelectric medicineElectrical therapyNociceptionParvalbumin interneuronsrTMSSensory gatingThalamic bursting

Identifiers

PMID29784588
PMCPMC6109414
OpenAlexW2803196812

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.