Trial reportJournal of cardiothoracic surgery2018
Positive impact of retrograde autologous priming in adult patients undergoing cardiac surgery: a randomized clinical trial.
Trial report in Journal of cardiothoracic surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Blood Conservation Protocol for Patients Undergoing Left Ventricular Assisted Device Implantation.Annals of cardiac anaesthesia · 2026Article
- Does retrograde autologous priming during coronary artery bypass grafting reduce blood transfusions?JTCVS open · 2025Article
- 2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- 2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Perioperative Considerations, Anesthetic Management and Transesophageal Echocardiographic Evaluation of Patients Undergoing the Ross Procedure.Journal of cardiovascular development and disease · 2025Review
- Intraoperative Autologous Blood Transfusion in Aortic Surgery.Aorta (Stamford, Conn.) · 2024Article
- Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention.Renal failure · 2024Review
- Adverse renal effects associated with cardiopulmonary bypass.Perfusion · 2024Review
- The attitudes about life-sustaining treatment among cardiac surgery ICU patients and their families.Frontiers in surgery · 2023Article
- Propensity-Matched Analysis of Del Nido Cardioplegia in Adults Undergoing Cardiac Surgery with Prolonged Cross-Clamping Time.Brazilian journal of cardiovascular surgery · 2022Article
- Lung injury after cardiopulmonary bypass: Alternative treatment prospects.World journal of clinical cases · 2022Review
- To RAP or Not to RAP: A Retrospective Comparison of the Effects of Retrograde Autologous Priming.The journal of extra-corporeal technology · 2021Article
- STS/SCA/AmSECT/SABM Update to the Clinical Practice Guidelines on Patient Blood Management.The journal of extra-corporeal technology · 2021Article
- Blood Conservation and Hemostasis Management in Pediatric Cardiac Surgery.Frontiers in cardiovascular medicine · 2021Review
- The Association of Matrix Metalloproteinases With Acute Kidney Injury Following CPB-Supported Cardiac Surgery.Canadian journal of kidney health and disease · 2021Article
- Implementation of a Prescriptive Extracorporeal Circuit and Its Effect on Hemodilution and Blood Product Usage during Cardiac Surgery.The journal of extra-corporeal technology · 2020Article
- Albumin Use After Cardiac Surgery.Critical care explorations · 2020Article
- The Effect of Standardizing Autologous Prime Techniques in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass.The journal of extra-corporeal technology · 2019Article
- Retrograde autologous priming method reduces plasma free hemoglobin level in aortic surgery.Annals of cardiac anaesthesiaArticle
- Myocardial protection in cardiac surgery: Del Nido versus blood cardioplegia.Annals of cardiac anaesthesiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdult cardiac surgery with extracorporeal circulation is known to be associated with increased risk of blood transfusion leading to adverse outcomes. Procedures like retrograde autologous priming (RAP) may reduce these negative side effects. This randomized prospective study was initiated to assess whether RAP using specifically designed RAP bag (Terumo) has immediate effects on patient outcome.
methodsOne hundred eighteen adults undergoing elective CABG or elective aortic valve replacement were randomly assigned by a computer program into two groups: the RAP group (n = 54) in which the retrograde autologous priming was applied and the non-RAP (n = 64) group in which the same setting was used without the possibility to save priming volume. Patient demographics, preoperative characteristics and postoperative outcomes were analyzed for both groups.
resultsThe primary endpoint defined as rate of intraoperative blood transfusion was significantly reduced in the RAP-group (p = 0.04). The absolute risk reduction for RAP managed patients was 13.5 percent points. There were no significant differences in operation time and blood loss. No deaths and no myocardial infarctions were observed. The number of patients needed to treat to prevent at least one red blood cell transfusion was around 8 (NNT = 7.42).
conclusionsRetrograde autologous priming is a safe and less invasive procedure which achieves clear benefits for adult cardiac surgery patients. In the light of increasing red blood cell transfusion risks and costs and the wish of patients to avoid a transfusion implementation of retrograde autologous priming is an interesting option.
trial registrationGerman Clinical Trials Register ID: DRKS00013512 , registered 04 December 2017.
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