Evidence map›Paper›PMID 29783986›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2018

Impact of the cone operation on left ventricular size, function, and dyssynchrony in Ebstein anomaly: a cardiovascular magnetic resonance study.

Rebecca S Beroukhim, Linyuan Jing, David M Harrild, Brandon K Fornwalt, Abba Mejia-Spiegeler, Jonathan Rhodes, Sitaram Emani, Andrew J Powell

Open access · goldAbstract read
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Guideline
  2. Article
  3. Role of speckle tracking imaging in risk stratification in Ebstein anomaly.International journal of cardiology. Congenital heart disease · 2026
    Article
  4. Article
  5. Biventricular remodeling and function after Cone repair of Ebstein Anomaly: A review.International journal of cardiology. Congenital heart disease · 2026
    Review
  6. Primary Tricuspid Regurgitation in ACHD: Diagnosis and Treatment.Methodist DeBakey cardiovascular journal · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
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  15. Article
  16. Journal of Cardiovascular Magnetic Resonance: 2017/2018 in review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019
    Review
  17. Early and Long-Term Outcomes of Surgical Treatment of Ebstein's Anomaly.Brazilian journal of cardiovascular surgery · 2019
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rebecca S BeroukhimDepartment of Pediatrics, Massachusetts General Hospital, 175 Cambridge Street, 5th Floor, Boston, MA, 02114, USA. rsberoukhim@partners.org.ORCID http://orcid.org/0000-0003-4053-8932
Linyuan JingDepartment of Imaging Science and Innovation, Geisinger, Danville, PA, USA.
David M HarrildDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Brandon K FornwaltDepartment of Imaging Science and Innovation, Geisinger, Danville, PA, USA.
Abba Mejia-SpiegelerDepartment of Imaging Science and Innovation, Geisinger, Danville, PA, USA.
Jonathan RhodesDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Sitaram EmaniDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA.
Andrew J PowellDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Boston Children's Hospital · USGeisinger Medical Center · US

Funding

Exploring the Role of Dyssynchrony in Pediatric Heart Disease with MRIDP5OD012132 · OD · UNIVERSITY OF KENTUCKY · PI FORNWALT, BRANDON K · 2012 to 2016
$2.2M
NIH HHS DP5 OD012132
6 · The paper itself

Abstract

backgroundIn addition to tricuspid regurgitation (TR) and right ventricular (RV) enlargement, patients with Ebstein anomaly are at risk for left ventricular (LV) dysfunction and dyssynchrony. We studied the impact of the cone tricuspid valve reconstruction operation on LV size, function, and dyssynchrony.

methodsAll Ebstein anomaly patients who had both pre- and postoperative cardiovascular magnetic resonance (CMR) studies were retrospectively identified. From cine images, RV and LV volumes and ejection fractions (EF) were calculated, and LV circumferential and longitudinal strain were measured by feature tracking. To quantify LV dyssynchrony, temporal offsets (TOs) were computed among segmental circumferential strain versus time curves using cross-correlation analysis and patient-specific reference curves. An LV dyssynchrony index was calculated as the standard deviation of the TOs.

resultsTwenty patients (65% female) were included with a median age at cone operation of 16 years, and a median time between pre- and postoperative CMR of 2.8 years. Postoperatively, there was a decline in the TR fraction (56 ± 19% vs. 5 ± 4%, p < 0.001), RV end-diastolic volume (EDV) (242 ± 110 ml/m

conclusionsIn patients with the Ebstein anomaly, the cone operation led to reduced TR and RV stroke volume, increased LV stroke volume, improved LV basal septal strain, and improved LV synchrony. Our data demonstrates that the detrimental effect of the RV on LV function can be mitigated by the cone operation.

Indexed as

Magnetic Resonance Imaging, CineMyocardial ContractionVentricular Function, LeftAdolescentAdultCardiac Surgical ProceduresChildChild, PreschoolEbstein AnomalyFemaleHeart VentriclesHumansMalePredictive Value of TestsRecovery of FunctionRetrospective StudiesCardiovascular magnetic resonanceCone operationDyssynchronyEbstein anomalyStrain

Identifiers

PMID29783986
PMCPMC5963144
OpenAlexW2807633283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.