ArticleBMC medicine2018
Informing real-world practice with real-world evidence: the value of PRECIS-2.
Article in BMC medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the methodological quality of randomised trials in IBD surgery.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Pooled it
- Increasing ketamine administration in children's hospitals for youth with sickle cell disease.Blood advances · 2026Article
- Integrating digital health and remote monitoring: emerging trends in cardiac rehabilitation research for chronic heart failure.Frontiers in cardiovascular medicine · 2026Article
- Lack of pragmatic attitude of self-labelled pragmatic trials on manual therapy: a methodological review.BMC medical research methodology · 2024Review
- Assessing the implementation and effectiveness of early integrated palliative care in long-term care facilities in France: an interventional mixed-methods study protocol.BMC palliative care · 2023Article
- Applying the PRECIS-2 tool for self-declared 'pragmatic' acupuncture trials: protocol for a systematic review.BMJ open · 2022Article
- An application of PRECIS-2 to evaluate trial design in a pilot cluster randomised controlled trial of a community-based smoking cessation intervention for women living in disadvantaged areas of Ireland.Pilot and feasibility studies · 2022Article
- Prescription of Anticholinergic Drugs in Patients With Schizophrenia: Analysis of Antipsychotic Prescription Patterns and Hospital Characteristics.Frontiers in psychiatry · 2022Article
- Core functions and forms of Bright IDEAS: A multi-methods evaluation of the adoption of an evidence-based psychosocial training program through iterative adaptation.Frontiers in health services · 2022Article
- Protocol refinement for a diabetes pragmatic trial using the PRECIS-2 framework.BMC health services research · 2021Article
- Designing provider-focused implementation trials with purpose and intent: introducing the PRECIS-2-PS tool.Implementation science : IS · 2021Article
- Lessons from Outside and Within: Exploring Advancements in Methodology for Naturopathic Medicine Clinical Research.Journal of alternative and complementary medicine (New York, N.Y.) · 2019Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Real-world evidence is needed to inform real-world practice. Pragmatic controlled trials are intended to provide such evidence by assessing the effectiveness of medicines and other interventions in real-world settings, as opposed to explanatory trials that assess efficacy in highly controlled settings. Dal-Ré and colleagues (BMC Med 16:49, 2018) recently performed a literature review of studies published between 2014 and 2017 to assess the degree to which studies that self-identified as pragmatic were truly so. The authors found that over one-third of randomized controlled trials of drugs and biologics that were self-labeled as pragmatic used placebo controls (as opposed to usual care), tested medicines before licensing, or were conducted in a single site. Further, they proposed that, in order to improve the reliability of the 'pragmatic' label, investigators should assess their trials using the PRECIS-2 tool upon submission to funders, ethics boards, or journals. We appreciate the value of PRECIS-2 as an indicator to assess the pragmatic versus explanatory features in a trial, and we herein highlight the potential challenges and opportunities that may arise with its systematic and widespread use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.