Evidence map›Paper›PMID 29783953›Full record

ArticleBMC infectious diseases2018

Immunologic and virological response to ART among HIV infected individuals at a tertiary hospital in Ghana.

Dorcas Obiri-Yeboah, Faustina Pappoe, Ibrahim Baidoo, Francis Arthur, Anna Hayfron-Benjamin, Samuel Essien-Baidoo, Godwin Kwakye-Nuako, Stephen Ayisi Addo

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In one paragraph

Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dorcas Obiri-YeboahDepartment of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana. d.obiri-yeboah@uccsms.edu.gh.ORCID 0000-0003-4562-9294
Faustina PappoeDepartment of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
Ibrahim BaidooPublic Health Unit, Cape Coast Teaching Hospital, Cape Coast, Ghana.
Francis ArthurMicrobiology Unit, Cape Coast Teaching Hospital, Cape Coast, Ghana.
Anna Hayfron-BenjaminDepartment of Maternal and Child Health, School of Nursing and Midwifery, University of Cape Coast, Cape Coast, Ghana.
Samuel Essien-BaidooDepartment of Laboratory Technology, University of Cape Coast, Cape Coast, Ghana.
Godwin Kwakye-NuakoDepartment of Biomedical Sciences, University of Cape Coast, Cape Coast, Ghana.
Stephen Ayisi AddoNational AIDS/STI Control Program, Ghana Health Services, Accra, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe need to study the outcome of Antiretroviral Therapy (ART) among Human Immunodeficiency Virus (HIV) infected individuals in Ghana, a sub-Saharan African country crucial in the era of the "Treat All" policy. The aim of this study was to analyze selected determinants of immunological and virological response to ART among HIV infected individuals in a tertiary facility in Cape Coast, Ghana.

methodsAn analytical cross sectional study with a retrospective component was conducted in the Cape Coast Teaching Hospital (CCTH), Central Region. Clients aged 18 years and above attending the HIV Clinics for ART and who were on ART for 6 months or more were recruited. The viral loads, CD4 count and other socio-demographic data were analyzed using STATA version 13 (STATA Corp, Texas USA). Descriptive analysis was done and presented with appropriate measures of central tendencies. In addition, bivariate and multivariate analysis was carried out with p value of 0.05 interpreted as evidence of association between variables.

resultsA total of 440 participants were included in this study with a mean age of 45.5 (±11.6) years. The mean CD4 count at baseline, 6 months on ART and currently at study recruitment were 215.1 cells/mm

conclusionThere was good response to ART among clients, high virological suppression and immunological recovery hence low rates of change to second line ART regimen in this cohort studied. With strict adherence to the national policy on HIV testing, management of positive clients and full implementation of the "Treat All" policy, Ghana could achieve, if nothing at all, the third "90, 90, 90" target by 2020.

Indexed as

Antiretroviral Therapy, Highly ActiveAdolescentAdultAnti-HIV AgentsCD4 Lymphocyte CountCross-Sectional StudiesFemaleGhanaHIV InfectionsHumansMaleMiddle AgedOdds RatioRetrospective StudiesRNA, ViralTertiary Care CentersAnti-HIV AgentsRNA, ViralAntiretroviral therapyCD4GhanaHIVViral load

Identifiers

PMID29783953
PMCPMC5963173

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.