Evidence map›Paper›PMID 29783786›Full record

ReviewNanomaterials (Basel, Switzerland)2018

Graphene-Based Nanomaterials for Tissue Engineering in the Dental Field.

Riccardo Guazzo, Chiara Gardin, Gloria Bellin, Luca Sbricoli, Letizia Ferroni, Francesco Saverio Ludovichetti, Adriano Piattelli, Iulian Antoniac, Eriberto Bressan, Barbara Zavan

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  4. Effects of adding graphene oxide to composite resin: An in vitrostudy.Acta odontologica latinoamericana : AOL · 2026
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  18. On the Use of Nanoparticles in Dental Implants.Materials (Basel, Switzerland) · 2024
    Review
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  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Riccardo GuazzoDepartment of Neurosciences, Institute of Clinical Dentistry, University of Padova, 35128 Padova, Italy. riccardo.guazzo@unipd.it.ORCID 0000-0001-8826-0162
Chiara GardinDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy. chiara.gardin@unipd.it.
Gloria BellinDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy. gloria.bellin@gmail.com.ORCID 0000-0001-7932-3205
Luca SbricoliDepartment of Neurosciences, Institute of Clinical Dentistry, University of Padova, 35128 Padova, Italy. luca.sbricoli@unipd.it.ORCID 0000-0003-2222-5764
Letizia FerroniDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy. letizia.ferroni@unipd.it.
Francesco Saverio LudovichettiDepartment of Neurosciences, Institute of Clinical Dentistry, University of Padova, 35128 Padova, Italy. francesco.ludovichetti@unipd.it.ORCID 0000-0003-4960-3534
Adriano PiattelliDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy. apiattelli@unich.it.
Iulian AntoniacDepartment Materials Science and Engineering, University Politehnica of Bucharest, 060032 Bucharest, Romania. antoniac.iulian@gmail.com.ORCID 0000-0003-0112-3494
Eriberto BressanDepartment of Neurosciences, Institute of Clinical Dentistry, University of Padova, 35128 Padova, Italy. eriberto.bressan@unipd.it.
Barbara ZavanDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy. barbara.zavan@unipd.it.ORCID 0000-0002-4779-4456

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The world of dentistry is approaching graphene-based nanomaterials as substitutes for tissue engineering. Apart from its exceptional mechanical strength, electrical conductivity and thermal stability, graphene and its derivatives can be functionalized with several bioactive molecules. They can also be incorporated into different scaffolds used in regenerative dentistry, generating nanocomposites with improved characteristics. This review presents the state of the art of graphene-based nanomaterial applications in the dental field. We first discuss the interactions between cells and graphene, summarizing the available in vitro and in vivo studies concerning graphene biocompatibility and cytotoxicity. We then highlight the role of graphene-based nanomaterials in stem cell control, in terms of adhesion, proliferation and differentiation. Particular attention will be given to stem cells of dental origin, such as those isolated from dental pulp, periodontal ligament or dental follicle. The review then discusses the interactions between graphene-based nanomaterials with cells of the immune system; we also focus on the antibacterial activity of graphene nanomaterials. In the last section, we offer our perspectives on the various opportunities facing the use of graphene and its derivatives in associations with titanium dental implants, membranes for bone regeneration, resins, cements and adhesives as well as for tooth-whitening procedures.

Indexed as

antibacterial activitybone regenerationdental implantdental stem cellsgraphenenanomaterials

Identifiers

PMID29783786
PMCPMC5977363

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.