Evidence map›Paper›PMID 29783778›Full record

ArticleMarine drugs2018

Anti-Tumorigenic and Anti-Metastatic Activity of the Sponge-Derived Marine Drugs Aeroplysinin-1 and Isofistularin-3 against Pheochromocytoma In Vitro.

Nicole Bechmann, Hermann Ehrlich, Graeme Eisenhofer, Andre Ehrlich, Stephan Meschke, Christian G Ziegler, Stefan R Bornstein

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
  5. Article
  6. Targeting one-carbon metabolism for cancer immunotherapy.Clinical and translational medicine · 2024
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  11. Calcite Nanotuned Chitinous Skeletons of GiantInternational journal of molecular sciences · 2021
    Article
  12. Review
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  14. Review
  15. Article
  16. Adrenal Hormone Interactions and Metabolism: A Single Sample Multi-Omics Approach.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nicole BechmannInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Nicole.bechmann@uniklinikum-dresden.de.ORCID 0000-0002-6932-333X
Hermann EhrlichInstitute of Experimental Physics, TU Bergakademie Freiberg, Leipziger 23, 09599 Freiberg, Germany. Hermann.Ehrlich@physik.tu-freiberg.de.
Graeme EisenhoferInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Graeme.eisenhofer@uniklinikum-dresden.de.
Andre EhrlichBromMarin GmbH, Wernerstraße 1, 09599 Freiberg, Germany. Andre.ehrlich@brommarin.de.
Stephan MeschkeBromMarin GmbH, Wernerstraße 1, 09599 Freiberg, Germany. Stephan.meschke@brommarin.de.ORCID 0000-0001-8726-6319
Christian G ZieglerDepartment of Medicine III, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Christian.ziegler@uniklinikum-dresden.de.
Stefan R BornsteinDepartment of Medicine III, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Stefan.bornstein@uniklinikum-dresden.de.
University Hospital Carl Gustav Carus · DETU Bergakademie Freiberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over 10% of pheochromocytoma and paraganglioma (PPGL) patients have malignant disease at their first presentation in the clinic. Development of malignancy and the underlying molecular pathways in PPGLs are poorly understood and efficient treatment strategies are missing. Marine sponges provide a natural source of promising anti-tumorigenic and anti-metastatic agents. We evaluate the anti-tumorigenic and anti-metastatic potential of Aeroplysinin-1 and Isofistularin-3, two secondary metabolites isolated from the marine sponge

Indexed as

AcetonitrilesAdrenal Gland NeoplasmsAlkaloidsAnimalsAntineoplastic AgentsCarcinogenesisCell AdhesionCell Line, TumorCell MovementCyclohexenesDown-RegulationIntegrin beta1MaleMicePheochromocytomaPoriferaAcetonitrilesaeroplysinin IAlkaloidsAntineoplastic AgentsCyclohexenesIntegrin beta1isofistularin-3Aeroplysinincancer progressioncell adhesion moleculeshypoxiaintegrin β1Isofistularinmarine spongesmetastasispheochromocytoma and paraganglioma

Identifiers

PMID29783778
PMCPMC5983303
OpenAlexW2803425946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.