ArticleJournal of functional biomaterials2018
Encapsulation and Characterization of Gentamicin Sulfate in the Collagen Added Electrospun Nanofibers for Skin Regeneration.
Article in Journal of functional biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Development of an Injectable Boronic Ester Nanocomposite Hydrogel for pH- and Thermo-Responsive Gentamicin Delivery and Antibacterial Activity.AAPS PharmSciTech · 2026Article
- Article
- Stepwise antibacterial strategy for orthopedic implants using bacteriophages on electrospun cefiderocol/PCl/Gt nanofibers over PEO-coated Mgnpj biomedical innovations · 2025Article
- Electrospun Polycaprolactone Membranes Loaded with Gentamicin and Nano-Hidroxyapatite for Guided Bone Regeneration.Biomedicines · 2025Article
- Bovine pulp extracellular matrix hydrogel for regenerative endodontic applications: in vitro characterization and in vivo analysis in a necrotic tooth model.Head & face medicine · 2024Article
- Article
- Morphology, Cytotoxicity, and Antimicrobial Activity of Electrospun Polycaprolactone Biomembranes with Gentamicin and Nano-Hydroxyapatite.Membranes · 2023Article
- Large-Scale Development of Antibacterial Scaffolds: Gentamicin Sulfate-Loaded Biodegradable Nanofibers for Gastrointestinal Applications.ACS omega · 2023Article
- Synthesis and Characterization of Ciprofloxacin Loaded Star-Shaped Polycaprolactone-Polyethylene Glycol Hydrogels for Oral Delivery.Micromachines · 2023Article
- Multilayer Methacrylate-Based Wound Dressing as a Therapeutic Tool for Targeted Pain Relief.Materials (Basel, Switzerland) · 2023Article
- PCL/Gelatin/Graphene Oxide Electrospun Nanofibers: Effect of Surface Functionalization on In Vitro and Antibacterial Response.Nanomaterials (Basel, Switzerland) · 2023Article
- Wool Keratin Nanofibers for Bioinspired and Sustainable Use in Biomedical Field.Journal of functional biomaterials · 2022Review
- Gentamicin-Ascorbic Acid Encapsulated in Chitosan Nanoparticles Improved In Vitro Antimicrobial Activity and Minimized Cytotoxicity.Antibiotics (Basel, Switzerland) · 2022Article
- The Preparation and Biological Testing of Novel Wound Dressings with an Encapsulated Antibacterial and Antioxidant Substance.Nanomaterials (Basel, Switzerland) · 2022Article
- 3D Scaffolds Fabrication via Bicomponent Microgels Assembly: Process Optimization andMicromachines · 2022Article
- Electrospun Sulfonatocalix[4]arene Loaded Blended Nanofibers: Process Optimization and In Vitro Studies.Pharmaceutics · 2022Article
- Antimicrobial Fibrous Bandage-like Scaffolds Using Clove Bud Oil.Journal of functional biomaterials · 2022Article
- Electrospun Polymer Nanofibers with Antimicrobial Activity.Polymers · 2022Review
- Design of Asymmetric Nanofibers-Membranes Based on Polyvinyl Alcohol and Wool-Keratin for Wound Healing Applications.Journal of functional biomaterials · 2021Article
- Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the current practice, the clinical use of conventional skin substitutes such as autogenous skin grafts have shown several problems, mainly with respect to limited sources and donor site morbidity. In order to overcome these limitations, the use of smart synthetic biomaterials is tremendously diffusing as skin substitutes. Indeed, engineered skin grafts or analogues frequently play an important role in the treatment of chronic skin wounds, by supporting the regeneration of newly formed tissue, and at the same time preventing infections during the long-term treatment. In this context, natural proteins such as collagen-natively present in the skin tissue-embedded in synthetic polymers (i.e., PCL) allow the development of micro-structured matrices able to mimic the functions and to structure of the surrounding extracellular matrix. Moreover, the encapsulation of drugs, such as gentamicin sulfate, also improves the bioactivity of nanofibers, due to the efficient loading and a controlled drug release towards the site of interest. Herein, we have done a preliminary investigation on the capability of gentamicin sulfate, loaded into collagen-added nanofibers, for the controlled release in local infection treatments. Experimental studies have demonstrated that collagen added fibers can be efficaciously used to administrate gentamicin for 72 h without any toxic in vitro response, thus emerging as a valid candidate for the therapeutic treatment of infected wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.