Evidence map›Paper›PMID 29783641›Full record

ArticleInternational journal of environmental research and public health2018

Premature Spinal Bone Loss in Women Living with HIV is Associated with Shorter Leukocyte Telomere Length.

Shirin Kalyan, Neora Pick, Alice Mai, Melanie C M Murray, Kristen Kidson, Jackson Chu, Arianne Y K Albert, Hélène C F Côté, Evelyn J Maan, Azita Goshtasebi and 2 more

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Can telomere length predict bone health? A review of current evidence.Bosnian journal of basic medical sciences · 2020
    Review
  8. Innovations in Women's Bone Health-Appreciating Important "Bone Variables" Besides Estrogen.International journal of environmental research and public health · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shirin KalyanDepartment of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada. shirin.kalyan@ubc.ca.ORCID 0000-0002-7332-2225
Neora PickOak Tree Clinic, British Columbia Women's Hospital, Vancouver, BC, V6H 3N1, Canada. npick@cw.bc.ca.
Alice MaiDepartment of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada. alice.y.mai@gmail.com.
Melanie C M MurrayOak Tree Clinic, British Columbia Women's Hospital, Vancouver, BC, V6H 3N1, Canada. Melanie.murray@cw.bc.ca.ORCID 0000-0001-9538-2758
Kristen KidsonDepartment of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada. kmsokalski@gmail.com.
Jackson ChuDepartment of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada. cts.jackson@gmail.com.
Arianne Y K AlbertBC Women's Health Research Institute, British Columbia Women's Hospital, Vancouver, BC V6H 3N1, Canada. Arianne.albert@cw.bc.ca.ORCID 0000-0002-3050-0888
Hélène C F CôtéBC Women's Health Research Institute, British Columbia Women's Hospital, Vancouver, BC V6H 3N1, Canada. hcote@pathology.ubc.ca.
Evelyn J MaanOak Tree Clinic, British Columbia Women's Hospital, Vancouver, BC, V6H 3N1, Canada. emaan@cw.bc.ca.
Azita GoshtasebiDivision of Endocrinology; Centre for Menstrual Cycle and Ovulation Research, BC Centre for the Canadian Multicentre Osteoporosis Study, University of British Columbia, Vancouver, BC V5Z 1M9, Canada. azita.goshtasebi@ubc.ca.
Deborah M MoneyOak Tree Clinic, British Columbia Women's Hospital, Vancouver, BC, V6H 3N1, Canada. deborah.money@ubc.ca.
Jerilynn C PriorDepartment of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada. jerilynn.prior@ubc.ca.ORCID 0000-0003-3232-0597

Funding

CIHR TCO 125269
6 · The paper itself

Abstract

With advances in combination antiretroviral therapy (cART), people living with HIV are now surviving to experience aging. Evidence suggests that individuals living with HIV are at greater risk for low bone mineral density (BMD), osteoporosis, and fractures. Better understanding of the pathophysiology of bone health in women living with HIV (WLWH) is important for treatment strategies. The goal of this study was to explore new biological factors linked to low BMD in WLWH. Standardized BMD measures of WLWH were compared to reference values from an unselected population of women from the same geographical region of the same age range. Linear regression analysis was used to assess relationships among health-related characteristics, cellular aging (measured by leukocyte telomere length; LTL), cART, and BMD of WLWH. WLWH (

Indexed as

Bone DensityTelomereAdultAnti-Retroviral AgentsCellular SenescenceFemaleHIV InfectionsHumansLeukocytesLumbar VertebraeMiddle AgedOsteoporosisAnti-Retroviral Agentsantiretroviral therapybone mineral densityHIV infectionleukocyte telomere lengthosteoporosiswomen

Identifiers

PMID29783641
PMCPMC5982057

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.