ArticlePLoS pathogens2018
Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection.
Article in PLoS pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- γδ T cells in oral diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Pooled it
- Pathogenicity and virulence ofVirulence · 2026Review
- An Integrated Platform for the Comprehensive Analysis of Host-Fungal Interactions in the Murine Tongue.Current protocols · 2026Article
- γδ T Cell-Mediated Neuroimmune Interactions in Skin Inflammation and Allergy.Clinical reviews in allergy & immunology · 2026Review
- Cutaneous Innate Lymphoid Populations Drive IL-17A-Mediated Immunity in Nannizzia gypsea Dermatophytosis.The Journal of investigative dermatology · 2025Article
- Amphibian (Journal of fungi (Basel, Switzerland) · 2025Article
- Epithelial RANKL Limits Experimental Periodontitis via Langerhans Cells.Journal of dental research · 2024Article
- RFX transcription factor in the human-associated yeast Candida albicans regulates adhesion to oral epithelium.Molecular microbiology · 2024Article
- Review
- The roles of tissue resident macrophages in health and cancer.Experimental hematology & oncology · 2024Review
- MHC-II presentation by oral Langerhans cells impacts intraepithelial Tc17 abundance andFrontiers in oral health · 2024Article
- γδ T cells respond directly and selectively to the skin commensal yeast Malassezia for IL-17-dependent fungal control.PLoS pathogens · 2024Article
- IκBζ is an essential mediator of immunity to oropharyngeal candidiasis.Cell host & microbe · 2023Article
- Tissue-specific macrophages: how they develop and choreograph tissue biology.Nature reviews. Immunology · 2023Review
- Pathogenesis and virulence ofVirulence · 2022Review
- A gut-oral microbiome-driven axis controls oropharyngeal candidiasis through retinoic acid.JCI insight · 2022Article
- Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity but Not Antifungal Host Defense.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Article
- Immunosurveillance of Candida albicans commensalism by the adaptive immune system.Mucosal immunology · 2022Review
- The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.FEMS microbiology reviews · 2021Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
The opportunistic fungal pathogen Candida albicans frequently causes diseases such as oropharyngeal candidiasis (OPC) in immunocompromised individuals. Although it is well appreciated that the cytokine IL-17 is crucial for protective immunity against OPC, the cellular source and the regulation of this cytokine during infection are still a matter of debate. Here, we directly visualized IL-17 production in the tongue of experimentally infected mice, thereby demonstrating that this key cytokine is expressed by three complementary subsets of CD90+ leukocytes: RAG-dependent αβ and γδ T cells, as well as RAG-independent ILCs. To determine the regulation of IL-17 production at the onset of OPC, we investigated in detail the myeloid compartment of the tongue and found a heterogeneous and dynamic mononuclear phagocyte (MNP) network in the infected tongue that consists of Zbtb46-Langerin- macrophages, Zbtb46+Langerin+ dendritic cells (DCs) and Ly6C+ inflammatory monocytes. Of those, the Langerin+ DC population stands out by its unique capacity to co-produce the cytokines IL-1β, IL-6 and IL-23, all of which promote IL-17 induction in response to C. albicans in the oral mucosa. The critical role of Langerin+ DCs for the innate IL-17 response was confirmed by depletion of this cellular subset in vivo, which compromised IL-17 induction during OPC. In conclusion, our work revealed key regulatory factors and their cellular sources of innate IL-17-dependent antifungal immunity in the oral mucosa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.