Trial reportBreastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine2018
Effects of Maternal Vitamin D Supplementation on the Maternal and Infant Epigenome.
Trial report in Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health.The Cochrane database of systematic reviews · 2020Pooled it
- Vitamin D in Breastfed Infants: Systematic Review of Alternatives to Daily Supplementation.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Preconception vitamin D status and subsequent risk of preeclampsia: A secondary cohort analysis from the EAGeR trial.Pregnancy hypertension · 2026Trial
- Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.The American journal of clinical nutrition · 2024Trial
- Maternal Vitamin D Status Correlates to Leukocyte Antigenic Responses in Breastfeeding Infants.Nutrients · 2022Trial
- Timing over Dose: Maternal Vitamin D, Periconceptional Window, and Early-Life Respiratory Programming.Nutrients · 2026Review
- Vitamin D-Related Signaling and Epigenetic Regulation: Evidence from Experimental, Observational, and Interventional Studies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- 25-Hydroxyvitamin DCommunications medicine · 2026Article
- Enhancing the Implementation of a high-quality randomized trial in pregnancy.Research square · 2026Article
- Diet during Pregnancy and Allergy Onset in the Childhood: A Systematic Literature Review and Meta-Analysis.International journal of preventive medicine · 2026Review
- Association between maternal vitamin D supplementation during pregnancy and the risk of acute respiratory infections in offspring: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Maternal influences on offspring food allergy.Immunological reviews · 2024Review
- Review
- Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics.International journal of molecular sciences · 2024Review
- Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes.Nature communications · 2023Article
- Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects.Biomedicines · 2022Review
- Nutrition during Pregnancy and Lactation: Epigenetic Effects on Infants' Immune System in Food Allergy.Nutrients · 2022Review
- Do Micronutrient and Omega-3 Fatty Acid Supplements Affect Human Maternal Immunity during Pregnancy? A Scoping Review.Nutrients · 2022Article
- Impact of dietary vitamin D on immunoregulation and disease pathology in lupus-prone NZB/W F1 mice.Frontiers in immunology · 2022Article
- Epigenetic regulation of pediatric and neonatal immune responses.Pediatric research · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
introductionMothers and infants are at high risk for inadequate vitamin D status. Mechanisms by which vitamin D may affect maternal and infant DNA methylation are poorly understood.
objectiveThis study quantified the effects of vitamin D MATERIALS AND
methodsIn this randomized controlled pilot study, pregnant women received vitamin D
resultsAt birth, intervention group mothers showed DNA methylation gain and loss at 76 and 89 cytosine-guanine (CpG) dinucleotides, respectively, compared to controls. Postpartum, methylation gain was noted at 200 and loss at 102 CpGs. Associated gene clusters showed strongest biologic relevance for cell migration/motility and cellular membrane function at birth and cadherin signaling and immune function at postpartum. Breastfed 4-6-week-old infants of intervention mothers showed DNA methylation gain and loss in 217 and 213 CpGs, respectively, compared to controls. Genes showing differential methylation mapped most strongly to collagen metabolic processes and regulation of apoptosis.
conclusionsMaternal vitamin D supplementation during pregnancy and lactation alters DNA methylation in mothers and breastfed infants. Additional work is needed to fully elucidate the short- and long-term biologic effects of vitamin D supplementation at varying doses, which could hold important implications for establishing clinical recommendations for prenatal and offspring health promotion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.