SynthesisJBRA assisted reproduction2018
Obstetric outcomes after fresh versus frozen-thawed embryo transfers: A systematic review and meta-analysis.
Synthesis in JBRA assisted reproduction, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Factors and outcomes for placental anomalies: An umbrella review of systematic reviews and meta-analyses.Journal of global health · 2024Pooled it
- Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses.BMC pregnancy and childbirth · 2021Pooled it
- Antenatal diagnosis of placenta accreta spectrum after in vitro fertilization-embryo transfer: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Fresh versus frozen embryo transfers in assisted reproduction.The Cochrane database of systematic reviews · 2021Pooled it
- The impact of embryo transfer modality and socioeconomic status on severe neonatal morbidity.Journal of assisted reproduction and genetics · 2026Article
- Article
- Treatment decisions, not patient demographics, predict a positive pregnancy test after autologous IVF: a retrospective cohort study from northern India.Frontiers in public health · 2026Article
- Reappraisal of adverse obstetric outcomes independently associated with contemporary fertility treatment practices: a US prospective cohort study.American journal of obstetrics and gynecology · 2026Article
- Hypertensive disorders of pregnancy and gestational diabetes mellitus affect fetal growth and perinatal outcomes in women undergoingAJOG global reports · 2025Article
- Is there a relationship between morphokinetic parameters and obstetrical complications? An analysis of singleton live births after single fresh embryo transfer.BMC pregnancy and childbirth · 2024Article
- Effect of progesterone concentration on hCG trigger day on clinical outcomes after high-quality single blastocyst transfer in GnRH antagonist cycles.Frontiers in medicine · 2024Article
- Obstetrical and Neonatal Outcomes of in vitro Fertilization Twins after Fresh Embryo Transfer versus Frozen-Thawed Embryo Transfer.Gynecologic and obstetric investigation · 2024Article
- Pregnancy by Oocyte Donation: Reviewing Fetal-Maternal Risks and Complications.International journal of molecular sciences · 2023Review
- Fresh or Frozen Embryo Transfer in The Antagonist In Vitro Fertilization Cycles: A Retrospective Cohort Study.International journal of fertility & sterility · 2022Article
- Implantation Failure in Endometriosis Patients: Etiopathogenesis.Journal of clinical medicine · 2022Review
- Society for Maternal-Fetal Medicine Consult Series #60: Management of pregnancies resulting from in vitro fertilization.American journal of obstetrics and gynecology · 2022Article
- Placenta Accreta Spectrum Disorder Complicated with Endometriosis: Systematic Review and Meta-Analysis.Biomedicines · 2022Review
- Maternal and neonatal outcomes followingExperimental and therapeutic medicine · 2022Article
- Placental Abnormalities and Placenta-Related Complications FollowingFrontiers in endocrinology · 2022Article
- Obstetric and Perinatal Complications Associated with Assisted Reproductive Techniques - Review.Maedica · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate if there are differences in the risks of obstetric outcomes in IVF/ICSI singleton pregnancies when compared fresh to frozen-thawed embryo transfers (FET).
methodsThis was a systematic review and meta-analysis evaluating the obstetric outcomes in singleton pregnancies after FET and fresh embryo transfer. The outcomes included in this study were pregnancy-induced hypertension (PIH), pre-eclampsia, placenta previa, and placenta accreta.
resultsThe search yielded 654 papers, 6 of which met the inclusion criteria and reported on obstetric outcomes. When comparing pregnancies that arose from FET or fresh embryo transfer, there was an increase in the risk of obstetric complications in pregnancies resulting from FET when compared to those emerging from fresh embryo transfers in PIH (aOR 1.82; 95% CI 1.24-2.68), pre-eclampsia (aOR 1.32, 95% CI 1.07, 1.63), and placenta accreta (aOR 3.51, 95% CI 2.04-6.05). There were no significant differences in the risk between the FET and fresh embryo transfer groups when evaluating placenta previa (aOR 0.70; 95% CI 0.46-1.08).
conclusionThe obstetric outcomes observed in pregnancies arising from ART may differ among fresh and FET cycles. Thus, when evaluating to perform a fresh embryo transfer or a freeze-all cycle, these differences found in obstetric outcomes between fresh and FET should be taken into account. The adverse obstetric outcomes after FET found in this study emphasize that the freeze-all policy should not be offered to all the patients, but should be offered to those with a clear indication of the benefit of this strategy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.