Evidence map›Paper›PMID 29782006›Full record

ArticleJournal of visualized experiments : JoVE2018

Neurovascular Network Explorer 2.0: A Simple Tool for Exploring and Sharing a Database of Optogenetically-evoked Vasomotion in Mouse Cortex In Vivo.

Hana Uhlirova, Peifang Tian, Kıvılcım Kılıç, Martin Thunemann, Vishnu B Sridhar, Radim Chmelik, Hauke Bartsch, Anders M Dale, Anna Devor, Payam A Saisan

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of visualized experiments : JoVE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hana UhlirovaDepartment of Radiology, University of California, San Diego; Central European Institute of Technology, Brno University of Technology; huhlirova1@gmail.com.
Peifang TianDepartment of Neurosciences, University of California, San Diego; Department of Physics, John Carroll University.
Kıvılcım KılıçDepartment of Neurosciences, University of California, San Diego; Department of Biomedical Engineering, Boston University.
Martin ThunemannDepartment of Radiology, University of California, San Diego.
Vishnu B SridharBioengineering Undergraduate Program, University of California, San Diego.
Radim ChmelikCentral European Institute of Technology, Brno University of Technology; Institute of Physical Engineering, Faculty of Mechanical Engineering, Brno University of Technology.
Hauke BartschDepartment of Radiology, University of California, San Diego.
Anders M DaleDepartment of Radiology, University of California, San Diego; Department of Neurosciences, University of California, San Diego.
Anna DevorDepartment of Radiology, University of California, San Diego; Department of Neurosciences, University of California, San Diego; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School.
Payam A SaisanDepartment of Neurosciences, University of California, San Diego.

Funding

Spatiotemporal Brain Imaging: Microscopic &System LevelR01EB000790 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M · 2002 to 2015
$15.3M
MICROSCOPIC FOUNDATION OF MULTIMODAL HUMAN IMAGINGR01MH111359 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M, DEVOR, ANNA · 2016 to 2020
$5.6M
Neuronal, glial and BOLD fMRI signals: From BOLD to 2-photon microscopyR01NS057198 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEVOR, ANNA · 2009 to 2017
$2.6M
Multiphoton imaging and uncaging system with a capability of simultaneous electroS10RR029050 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M · 2010 to 2010
$870k
NCRR NIH HHS S10 RR029050NIBIB NIH HHS R01 EB000790NIMH NIH HHS R01 MH111359NINDS NIH HHS R01 NS057198
6 · The paper itself

Abstract

The importance of sharing experimental data in neuroscience grows with the amount and complexity of data acquired and various techniques used to obtain and process these data. However, the majority of experimental data, especially from individual studies of regular-sized laboratories never reach wider research community. A graphical user interface (GUI) engine called Neurovascular Network Explorer 2.0 (NNE 2.0) has been created as a tool for simple and low-cost sharing and exploring of vascular imaging data. NNE 2.0 interacts with a database containing optogenetically-evoked dilation/constriction time-courses of individual vessels measured in mice somatosensory cortex in vivo by 2-photon microscopy. NNE 2.0 enables selection and display of the time-courses based on different criteria (subject, branching order, cortical depth, vessel diameter, arteriolar tree) as well as simple mathematical manipulation (e.g. averaging, peak-normalization) and data export. It supports visualization of the vascular network in 3D and enables localization of the individual functional vessel diameter measurements within vascular trees. NNE 2.0, its source code, and the corresponding database are freely downloadable from UCSD Neurovascular Imaging Laboratory website

Indexed as

AnimalsCerebral CortexDatabases, FactualMiceNeural Networks, ComputerSomatosensory CortexVasomotor System

Identifiers

PMID29782006
PMCPMC6101108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.