Evidence map›Paper›PMID 29781991›Full record

ArticleJournal of visualized experiments : JoVE2018

Retroductal Nanoparticle Injection to the Murine Submandibular Gland.

Jomy J Varghese, Isaac L Schmale, Yuchen Wang, Mollie Eva Hansen, Shawn D Newlands, Catherine E Ovitt, Danielle S W Benoit

Open access · greenAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of visualized experiments : JoVE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Salivary Gland Bioengineering.Bioengineering (Basel, Switzerland) · 2023
    Review
  5. Article
  6. Journal of clinical medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jomy J VargheseDepartment of Biomedical Engineering, University of Rochester; jomy_varghese@urmc.rochester.edu.
Isaac L SchmaleDepartment of Otolaryngology Head and Neck Surgery, University of Rochester Medical Center.
Yuchen WangDepartment of Biomedical Engineering, University of Rochester.
Mollie Eva HansenDepartment of Biomedical Engineering, University of Rochester.
Shawn D NewlandsDepartment of Otolaryngology Head and Neck Surgery, University of Rochester Medical Center.
Catherine E OvittCenter for Oral Biology, University of Rochester Medical Center.
Danielle S W BenoitDepartment of Biomedical Engineering, University of Rochester.
University of Rochester · USUniversity of Rochester Medical Center · US

Funding

Engineered salivary gland tissue chipsUG3DE027695 · NIDCR · UNIVERSITY OF ROCHESTER · PI BENOIT, DANIELLE S., DELOUISE, LISA A · 2017 to 2018
$1.5M
Salivary gland-specific radioprotectionR56DE025098 · NIDCR · UNIVERSITY OF ROCHESTER · PI BENOIT, DANIELLE S., OVITT, CATHERINE · 2016 to 2016
$531k
Engineered Nanoparticles to Radioprotect Salivary TissueF30CA206296 · NCI · UNIVERSITY OF ROCHESTER · PI VARGHESE, JOMY JO · 2016 to 2019
$192k
NCI NIH HHS F30 CA206296NIDCR NIH HHS R56 DE025098NIDCR NIH HHS UG3 DE027695
6 · The paper itself

Abstract

Two common goals of salivary gland therapeutics are prevention and cure of tissue dysfunction following either autoimmune or radiation injury. By locally delivering bioactive compounds to the salivary glands, greater tissue concentrations can be safely achieved versus systemic administration. Furthermore, off target tissue effects from extra-glandular accumulation of material can be dramatically reduced. In this regard, retroductal injection is a widely used method for investigating both salivary gland biology and pathophysiology. Retroductal administration of growth factors, primary cells, adenoviral vectors, and small molecule drugs has been shown to support gland function in the setting of injury. We have previously shown the efficacy of a retroductally injected nanoparticle-siRNA strategy to maintain gland function following irradiation. Here, a highly effective and reproducible method to administer nanomaterials to the murine submandibular gland through Wharton's duct is detailed (Figure 1). We describe accessing the oral cavity and outline the steps necessary to cannulate Wharton's duct, with further observations serving as quality checks throughout the procedure.

Indexed as

AnimalsHumansMiceMice, Inbred C57BLNanoparticlesSubmandibular Gland

Identifiers

PMID29781991
PMCPMC5999329
OpenAlexW2801282855

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.