ArticleJournal of the South African Veterinary Association2018
Immunological response to Brucella abortus strain 19 vaccination of cattle in a communal area in South Africa.
Article in Journal of the South African Veterinary Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Brucellosis vaccine development: immunological mechanisms, animal models, and future directions.Archives of microbiology · 2026Review
- Reverse vaccinology-driven construction and bioinformatics validation of a multi-epitope vaccine against Brucella spp.Scientific reports · 2025Article
- Comparison of Long-Term Antibody Titers in Calves Treated with Different Conjunctival and SubcutaneousAnimals : an open access journal from MDPI · 2025Article
- Brucellosis: Unveiling the complexities of a pervasive zoonotic disease and its global impacts.Open veterinary journal · 2024Review
- Polyphasic Characterization ofMicroorganisms · 2024Article
- Seroprevalence of brucellosis in communal and smallholder cattle farming in North West Province, South Africa.The Onderstepoort journal of veterinary research · 2023Article
- Brucellosis in the Brazilian Pantanal wetland: threat to animal production and wildlife conservation.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Review
- Seroprevalence to common infectious abortifacient and infertility causing agents in the dairy herds of India.Iranian journal of veterinary research · 2022Article
- Characterisation of Brucella species and biovars in South Africa between 2008 and 2018 using laboratory diagnostic data.Veterinary medicine and science · 2021Article
- Whole Genome Sequence Analysis ofMicroorganisms · 2021Article
- A retrospective sero-epidemiological survey of bovine brucellosis on commercial and communal farming systems in Namibia from 2004 to 2018.Tropical animal health and production · 2020Article
- Seroprevalence and characterization of Brucella species in cattle slaughtered at Gauteng abattoirs, South Africa.Veterinary medicine and science · 2019Article
- Immune Response to MucosalFrontiers in immunology · 2019Review
- Prevalence and risk factors for brucellosis seropositivity in cattle in Nyagatare District, Eastern Province, Rwanda.Journal of the South African Veterinary Association · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brucellosis is of worldwide economic and public health importance. Heifer vaccination with live attenuated Brucella abortus strain 19 (S19) is the cornerstone of control in low- and middle-income countries. Antibody persistence induced by S19 is directly correlated with the number of colony-forming units (CFU) per dose. There are two vaccination methods: a 'high' dose (5-8 × 1010 CFU) subcutaneously injected or one or two 'low' doses (5 × 109 CFU) through the conjunctival route. This study aimed to evaluate serological reactions to the 'high' dose and possible implications of the serological findings on disease control. This study included 58 female cases, vaccinated at Day 0, and 29 male controls. Serum was drawn repeatedly and tested for Brucella antibodies using the Rose Bengal Test (RBT) and an indirect enzyme-linked immunosorbent assay (iELISA). The cases showed a rapid antibody response with peak RBT positivity (98%) at 2 weeks and iELISA (95%) at 8 weeks, then decreased in an inverse logistic curve to 14% RBT and 32% iELISA positive at 59 weeks and at 4.5 years 57% (4/7 cases) demonstrated a persistent immune response (RBT, iELISA or Brucellin skin test) to Brucella spp. Our study is the first of its kind documenting the persistence of antibodies in an African communal farming setting for over a year to years after 'high' dose S19 vaccination, which can be difficult to differentiate from a response to infection with wild-type B. abortus. A recommendation could be using a 'low' dose or different route of vaccination.
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