Evidence map›Paper›PMID 29781387›Full record

ArticleCell adhesion & migration2018

Estrogen related receptor alpha triggers the migration and invasion of endometrial cancer cells via up regulation of TGFB1.

Xiumin Huang, Xuelian Wang, Jing Shang, Zhiqin Zhaang, Binbin Cui, Yanzhen Lin, Ying Yang, Youyi Song, Shengnan Yu, Junjie Xia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell adhesion & migration, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiumin Huanga Department of Gynecology and Obstetrics , Zhongshan Hospital of Xiamen University , Xiamen , China.
Xuelian Wanga Department of Gynecology and Obstetrics , Zhongshan Hospital of Xiamen University , Xiamen , China.
Jing Shanga Department of Gynecology and Obstetrics , Zhongshan Hospital of Xiamen University , Xiamen , China.
Zhiqin Zhaanga Department of Gynecology and Obstetrics , Zhongshan Hospital of Xiamen University , Xiamen , China.
Binbin Cuia Department of Gynecology and Obstetrics , Zhongshan Hospital of Xiamen University , Xiamen , China.
Yanzhen Lina Department of Gynecology and Obstetrics , Zhongshan Hospital of Xiamen University , Xiamen , China.
Ying Yanga Department of Gynecology and Obstetrics , Zhongshan Hospital of Xiamen University , Xiamen , China.
Youyi Songa Department of Gynecology and Obstetrics , Zhongshan Hospital of Xiamen University , Xiamen , China.
Shengnan Yua Department of Gynecology and Obstetrics , Zhongshan Hospital of Xiamen University , Xiamen , China.
Junjie Xiab Organ Transplantation Institute, Xiamen University , No. 308, Xiang'an South Road, Xiamen City , Fujian Province , China.
Zhongshan Hospital of Xiamen University · CNXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estrogenic signals have been suggested to be important for the tumorigenesis and progression of endometrial cancer (EC) cells. Our present data showed that estrogen related receptor alpha (ERRα), while not ERRβ or ERRγ, was significantly elevated in EC cells and tissues when compared to their controls. Targeted inhibition of ERRα by siRNA or its inverse agonist XCT-790 can suppress the migration and invasion of EC cells. Both si-ERRα and XCT-790 decreased the expression of transforming growth factor-beta (TGF-β). ERRα can directly bind with the promoter of TGFB1 and then increase its transcription. Further, ERRα was involved in the positive self-feedback loop of TGF-β in EC cells. Targeted inhibition of ERRα/TGF-β can synergistically suppress the in vitro invasion of EC cells. Collectively, our data suggested that ERRα can trigger the cell migration and invasion via increasing the positive self-feedback regulation of TGF-β.

Indexed as

Cell MovementCell ProliferationEndometrial NeoplasmsERRalpha Estrogen-Related ReceptorEstrogensFemaleHumansReceptors, EstrogenTransforming Growth Factor beta1ERRalpha Estrogen-Related ReceptorEstrogensReceptors, EstrogenTGFB1 protein, humanTransforming Growth Factor beta1endometrial cancerERRαinvasionmigrationTGF-β

Identifiers

PMID29781387
PMCPMC6363028
OpenAlexW2803904616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.