Evidence map›Paper›PMID 29781368›Full record

ReviewSmall GTPases2020

The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia.

Fabian R Villagomez, Oscar Medina-Contreras, Jorge Francisco Cerna-Cortes, Genaro Patino-Lopez

Open access · bronzeAbstract readReview
In one paragraph

Review in Small GTPases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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  15. The Endosomal Recycling Pathway-At the Crossroads of the Cell.International journal of molecular sciences · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Fabian R VillagomezLaboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez , Ciudad de México, México.ORCID 0000-0002-4510-1329
Oscar Medina-ContrerasLaboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez , Ciudad de México, México.ORCID 0000-0002-4432-7780
Jorge Francisco Cerna-CortesLaboratorio de Microbiología Molecular, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prolongación Carpio y Plan de Ayala S/N, Col. Casco de Santo Tomas , Ciudad de México, México.ORCID 0000-0002-4350-9507
Genaro Patino-LopezLaboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez , Ciudad de México, México.ORCID 0000-0002-8716-722X
Hospital Infantil de México Federico Gómez · MXInstituto Politécnico Nacional · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the "hallmarks of cancer" but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role that RabGTPases might play in some hallmarks of cancer represents interesting areas of study since these proteins are frequently altered in cancer. However, their participation is not well known. Recently, Rab35was recognized as an oncogenic RabGTPase and and because of its association with different cellular functions, distinctly important in immune cells, a possible role of Rab35 in leukemia can be suggested. Nevertheless, the involvement of Rab35 in cancer remains poorly understood and its possible specific role in leukemia remains unknown. In this review, we analyze general aspects of the participation of RabGTPases in cancer, and especially, the plausible role of Rab35 in leukemia.

Indexed as

HumansLeukemiarab GTP-Binding ProteinsRAB35 protein, humanrab GTP-Binding Proteinsactin dynamicsArf6cancer invasionCdc42Epi64Cexosomesimmune evasionleukemiametastasisRab35RabGTPasesRac1vesicular trafficking

Identifiers

PMID29781368
PMCPMC7549652
OpenAlexW2804788389

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.