Evidence map›Paper›PMID 29781223›Full record

ArticleHippocampus2018

Delayed injury of hippocampal interneurons after neonatal hypoxia-ischemia and therapeutic hypothermia in a murine model.

Raul Chavez-Valdez, Paul Emerson, Janasha Goffigan-Holmes, Alfredo Kirkwood, Lee J Martin, Frances J Northington

Abstract read
In one paragraph

Article in Hippocampus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
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  5. Review
  6. Correspondence on "Gabapentin for Delirium in Infants in the Neonatal Intensive Care Unit".The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025
    Article
  7. Abnormal Local Cortical Functional Connectivity due to Interneuron Dysmaturation after Neonatal Intermittent Hypoxia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. SMYD5 is a regulator of the mild hypothermia response.bioRxiv : the preprint server for biology · 2024
    Article
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Raul Chavez-ValdezDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0002-0788-8028
Paul EmersonDepartment of Neuroscience, The Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, Maryland.
Janasha Goffigan-HolmesDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland.
Alfredo KirkwoodDepartment of Neuroscience, The Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, Maryland.
Lee J MartinDepartment of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland.
Frances J NorthingtonDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USKennedy Krieger Institute · US

Funding

Adult Biomarkers in Neonatal Brain Injury and DevelopmentR01HD086058 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D, NORTHINGTON, FRANCES J · 2016 to 2020
$3.1M
Mechanisms of Hypothermic Neuroprotection in NeonatesR01HD070996 · NICHD · JOHNS HOPKINS UNIVERSITY · PI NORTHINGTON, FRANCES J · 2012 to 2016
$1.7M
Injury of Hippocampal Interneurons following Neonatal Hypoxia-Ischemia and Therapeutic HypothermiaK08NS096115 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CHAVEZ-VALDEZ, RAUL · 2017 to 2021
$1.2M
NICHD NIH HHS R01 HD070996NICHD NIH HHS R01 HD086058NINDS NIH HHS K08 NS096115
6 · The paper itself

Abstract

Delayed hippocampal injury and memory impairments follow neonatal hypoxia-ischemia (HI) despite the use of therapeutic hypothermia (TH). Death of hippocampal pyramidal cells occurs acutely after HI, but characterization of delayed cell death and injury of interneurons (INs) is unknown. We hypothesize that injury of INs after HI is: (i) asynchronous to that of pyramidal cells, (ii) independent of injury severity, and (iii) unresponsive to TH. HI was induced in C57BL6 mice at p10 with unilateral right carotid ligation and 45 min of hypoxia (FiO

Indexed as

AnimalsAnimals, NewbornCalbindin 1Disease Models, AnimalDisks Large Homolog 4 ProteinFunctional LateralityGene ExpressionGlial Fibrillary Acidic ProteinHippocampusHypothermia, InducedHypoxia-Ischemia, BrainInterneuronsMiceMice, Inbred C57BLParvalbuminsTubulinCalbindin 1Disks Large Homolog 4 ProteinDlg4 protein, mouseGlial Fibrillary Acidic ProteinParvalbuminsTubulinTumor Necrosis Factor-alphaVesicular Glutamate Transport Proteinscalbindindeveloping brainGABAergic neuronsmemoryparvalbumin

Identifiers

PMID29781223
PMCPMC6432630
OpenAlexW2803919537

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.