ArticlePediatric obesity2018
Newborn adipokines and early childhood growth.
Article in Pediatric obesity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Placental insulin-mTOR and stress-inflammatory signaling patterns are associated with childhood adiposity.BMC medicine · 2026Article
- Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood.Pediatric research · 2023Article
- Cord blood leptin level and a common variant of its receptor as determinants of the BMI trajectory: The EDEN mother-child cohort.Pediatric obesity · 2022Article
- Cord blood adiponectin and leptin are associated with a lower risk of stunting during infancy.Scientific reports · 2022Article
- Maternal diet quality during pregnancy is associated with biomarkers of metabolic risk among male offspring.Diabetologia · 2021Article
- Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life.European journal of nutrition · 2021Article
- Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels.International journal of molecular sciences · 2020Article
- Penalized regression models to select biomarkers of environmental enteric dysfunction associated with linear growth acquisition in a Peruvian birth cohort.PLoS neglected tropical diseases · 2019Article
- Early Life Exposures to Perfluoroalkyl Substances in Relation to Adipokine Hormone Levels at Birth and During Childhood.The Journal of clinical endocrinology and metabolism · 2019Article
- Neonatal Adipocytokines and Longitudinal Patterns of Childhood Growth.Obesity (Silver Spring, Md.) · 2019Article
- An Update on the Emerging Role of Resistin on the Pathogenesis of Osteoarthritis.Mediators of inflammation · 2019Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWhile adipokines can regulate satiety and energy metabolism, whether they are associated with childhood growth is unclear.
objectiveTo evaluate whether adipokine levels at birth are associated with growth.
methodsA total of 2264 singletons and 1144 twins from Upstate KIDS (born 2008-2010) had adiponectin, leptin, resistin and complement factor D measured in newborn blood spots. Parents reported anthropometry from paediatric visits via questionnaires every 4-6 months. Generalized linear mixed effects models were used to estimate growth trajectories through 3 years of age.
resultsAmong singletons, resistin and leptin were associated with greater weight-for-age (0.12 z-score units (95%CI: 0.04, 0.20) [p = 0.003] and 0.15 (0.06, 0.24) [p = 0.001], respectively) and BMI z-score (0.11; 0.02, 0.20 [p = 0.02] and 0.18; 0.07, 0.28 [p = 0.002], respectively). After adjusting for birthweight, resistin and a ratio of resistin-to-adiponectin remained associated with weight through 3 years of age and odds of being overweight at 3 years of age in a subgroup of singletons. Among twins, adiponectin was associated with increased weight-for-age and length-for-age z-scores even after adjusting for birthweight (0.18; 0.08, 0.28 [p = 0.0006]; 0.20; 0.07, 0.33 [p = 0.003], respectively).
conclusionsLevels of adipokines were associated with early childhood growth in small magnitudes. Resistin may be relevant for further examination in paediatric obesity.
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