ArticleJournal of intellectual disability research : JIDR2018
Early gesture use in fragile X syndrome.
Article in Journal of intellectual disability research : JIDR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- [Towards an early differential diagnosis in autism spectrum disorders and fragile X syndrome. A systematic review].Revista de neurologia · 2022Pooled it
- Autism and Epilepsy in Patients With Tuberous Sclerosis Complex.Frontiers in neurology · 2020Pooled it
- Modeling Longitudinal Trajectories of Word Production With the CDI.Developmental science · 2025Article
- Communication in fragile X syndrome: Patterns and implications for assessment and intervention.Frontiers in psychology · 2022Review
- Characterizing the Richness of Maternal Input for Word Learning in Neurogenetic Disorders.Seminars in speech and language · 2021Article
- Emergence and rate of autism in fragile X syndrome across the first years of life.Development and psychopathology · 2020Article
- Acoustic properties of early vocalizations in infants with fragile X syndrome.Autism research : official journal of the International Society for Autism Research · 2019Article
- Early Clinical Predictors of Autism Spectrum Disorder in Infants with Tuberous Sclerosis Complex: Results from the EPISTOP Study.Journal of clinical medicine · 2019Article
- Early communication development in infants and toddlers with Fragile X syndrome.Autism & developmental language impairmentsArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEmerging evidence suggests that children with fragile X syndrome (FXS) exhibit abnormal gesture use early in development, although few studies have investigated the emergence of gesture use in this population or the impact of autism spectrum disorder (ASD) features on these behaviours. The present study examined the longitudinal development of gesture use in infants with FXS relative to low-risk controls and infant siblings of children with ASD (high-risk siblings), with the goal of establishing potentially unique patterns of gesture development in infants with FXS and understanding the relative impact of ASD symptom severity on these patterns.
methodParticipants included 86 male infants (39 FXS, 27 high-risk siblings and 20 low-risk infants) assessed at 9, 12 and 24 months of age. Multilevel modelling was used to assess differences in number of gestures used and rates of gesture use across groups, as well as the relative impact of ASD symptom severity and nonverbal skills on these patterns.
resultsInfants with FXS used fewer gestures than high-risk siblings and low-risk infants, with this difference being primarily accounted for by the effect of low nonverbal abilities in the FXS group. Furthermore, although higher ASD symptom severity was associated with the use of fewer gestures in both the FXS and high-risk sibling groups, a significant amount of variance was shared between ASD symptom severity and nonverbal skills in FXS, but not in high-risk siblings.
conclusionsThis study presents the first longitudinal analysis of early gesture development in FXS by using a multigroup design, clarifying the relative roles of cognitive deficits and ASD symptom severity in the development of gesture use in FXS. These findings offer novel evidence that early gesture use in FXS may reflect broader features of the FXS phenotype rather than predicting later social-communicative deficits characteristic of comorbid ASD.
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Registered trials
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