ArticleAmerican journal of ophthalmology case reports2018
Unilateral paraneoplastic optic disc edema and retinal periphlebitis in pineal germinoma.
Article in American journal of ophthalmology case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 4 citations in OpenAlex.
- Masquerade Syndrome Presenting as Optic Neuritis and Retinitis Due to Pituitary Germinoma.Cureus · 2026Article
- Diagnosis and Management of Pineal Germinoma: From Eye to Brain.Eye and brain · 2023Review
- Paraneoplastic syndrome in neuroophthalmology.Journal of neurology · 2022Review
- A case of bilateral uveitis associated with seminoma/germinoma in thymus and pineal glands, two primary lesions.American journal of ophthalmology case reports · 2022Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe a unilateral ocular paraneoplastic syndrome in pineal germinoma. OBSERVATIONS: A 24-year-old male presented with diplopia, excessive thirst, and frequent urination. Cranial MRI showed a mass in pineal gland. Dorsal midbrain syndrome signs were present. Examination showed optic disc edema and segmental retinal periphlebitis in right and normal fundus in left eye. Rheumatologic work-up was negative. Brain biopsy confirmed pineal germinoma. Retinal findings were attributed to paraneoplastic syndrome. Resolution of optic disc edema and retinal periphlebitis occurred following chemotherapy and focal irradiation.
conclusionsand importance: To date there are two published case reports on bilateral optic disc edema and retinal periphlebitis occurring as a paraneoplastic syndrome in pineal germinoma. This is the first report on a patient with pineal germinoma who had unilateral paraneoplastic involvement characterized by optic disc edema and retinal periphlebitis and who showed complete resolution of ocular disease after treatment of underlying tumor.
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