Evidence map›Paper›PMID 29780872›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018

Neuropsychology and neuroimaging profiles of amyloid-positive versus amyloid-negative amnestic mild cognitive impairment patients.

Clémence Tomadesso, Vincent de La Sayette, Robin de Flores, Pierrick Bourgeat, Victor L Villemagne, Stéphanie Egret, Francis Eustache, Gaël Chételat

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

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  6. Steeper memory decline after COVID-19 lockdown measures.Alzheimer's research & therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Clémence TomadessoInserm, Inserm U1077, Université de Caen Normandie, Ecole Pratique des Hautes Etudes, Caen, France.
Vincent de La SayetteInserm, Inserm U1077, Université de Caen Normandie, Ecole Pratique des Hautes Etudes, Caen, France.
Robin de FloresInserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Boulevard H. Becquerel, Caen, France.
Pierrick BourgeatCSIRO Digital Productivity Flagship, The Australian e-Health Research Centre-BioMedIA, Herston, Queensland, Australia.
Victor L VillemagneDepartment of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
Stéphanie EgretInserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Boulevard H. Becquerel, Caen, France.
Francis EustacheInserm, Inserm U1077, Université de Caen Normandie, Ecole Pratique des Hautes Etudes, Caen, France.
Gaël ChételatInserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Boulevard H. Becquerel, Caen, France.
Inserm · FRUniversité de Caen Normandie · FRAustin Health · AUAustralian e-Health Research Centre · AUCyceron · FRÉcole Pratique des Hautes Études · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPatients with amnestic mild cognitive impairment (aMCI) are heterogeneous as regard to their amyloid status. The present study aimed at highlighting the neuropsychological, brain atrophy, and hypometabolism profiles of amyloid-positive (Aβpos) versus amyloid-negative (Aβneg) aMCI patients.

methodsForty-four aMCI patients and 24 Aβneg healthy controls underwent neuropsychological, structural magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography scans. Data were compared between groups in specific regions of interest and voxelwise with statistical parametric mapping.

resultsWhen directly comparing Aβpos to Aβneg aMCI, the former had lower performances in episodic memory tests (

conclusionIn a sample of aMCI patients recruited and scanned in the same center, the main difference at baseline between Aβpos and Aβneg aMCI concerned the neuropsychological profile, but not the structural magnetic resonance imaging or 18F-fluorodeoxyglucose positron emission tomography profiles of brain alterations.

Indexed as

Alzheimer's diseaseAmnestic mild cognitive impairmentAmyloid statusCognitionGlucose metabolismGray matter volume

Identifiers

PMID29780872
PMCPMC5956939
OpenAlexW2790342561

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.