Evidence map›Paper›PMID 29780862›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018

Hospitalization in people with dementia with Lewy bodies: Frequency, duration, and cost implications.

Christoph Mueller, Gayan Perera, Anto P Rajkumar, Manorama Bhattarai, Annabel Price, John T O'Brien, Clive Ballard, Robert Stewart, Dag Aarsland

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Phase 2 study of zervimesine (CT1812) in participants with mild-to-moderate dementia with Lewy bodies (DLB).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Trial
  6. Trial
  7. Lewy body dementia promotion by air pollutants.Science (New York, N.Y.) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Review
  15. Article
  16. End-of-Life Healthcare Utilization in Lewy Body Dementia.Journal of Alzheimer's disease : JAD · 2024
    Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Christoph MuellerKing's College London, London, United Kingdom.
Gayan PereraKing's College London, London, United Kingdom.
Anto P RajkumarKing's College London, London, United Kingdom.
Manorama BhattaraiBarnet, Enfield and Haringey Mental Health Trust, London, United Kingdom.
Annabel PriceUniversity of Cambridge, Cambridge, United Kingdom.
John T O'BrienUniversity of Cambridge, Cambridge, United Kingdom.
Clive BallardKing's College London, London, United Kingdom.
Robert StewartKing's College London, London, United Kingdom.
Dag AarslandKing's College London, London, United Kingdom.
King's College London · GBUniversity of Cambridge · GBBarnet Enfield and Haringey Mental Health Trust · GBSouth London and Maudsley NHS Foundation Trust · GB

Funding

Medical Research Council MC_PC_17214
6 · The paper itself

Abstract

introductionIncreased hospitalization is a major component of dementia impact on individuals and cost, but has rarely been studied in dementia with Lewy bodies (DLB). Our aim was to describe the risk and duration of hospital admissions in patients with DLB, and compare these to those in Alzheimer's disease (AD) and the general population.

methodsA large database of mental health and dementia care in South London was used to assemble a cohort of patients diagnosed with DLB. These were 1:4 matched with patients diagnosed with AD on age, gender, and cognitive status.

resultsRates of hospital admissions in the year after dementia diagnosis were significantly higher in 194 patients with DLB than in 776 patients with AD (crude incidence rate ratio 1.50; 95% confidence interval: 1.28-1.75) or the catchment population (indirectly standardized hospitalization rate 1.22; 95% confidence interval: 1.06-1.39). Patients with DLB had on average almost four additional hospital days per person-year than patients with AD. Multivariate Poisson regression models indicated poorer physical health early in the disease course as the main driver of this increased rate of hospitalization, whereby neuropsychiatric symptoms additionally explained the higher number of hospital days. DISCUSSION: Patients with DLB are more frequently admitted to general hospitals and utilize inpatient care to a substantially higher degree than patients with AD or the general elderly population. These data highlight an opportunity to reduce hospital days by identifying DLB earlier and providing more targeted care focused on the specific triggers for hospitalization and associations of prolonged stay.

Indexed as

ComorbidityDementia with Lewy bodiesHealth-care costsHealth servicesHospitalization

Identifiers

PMID29780862
PMCPMC5956805
OpenAlexW2780842894

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.