Evidence map›Paper›PMID 29780858›Full record

ReviewAlzheimer's & dementia (Amsterdam, Netherlands)2018

Can visuospatial measures improve the diagnosis of Alzheimer's disease?

Shirin Salimi, Muireann Irish, David Foxe, John R Hodges, Olivier Piguet, James R Burrell

Abstract readReview
In one paragraph

Review in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Visual field defects in dementia: A scoping review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Adaptive and Maladaptive Behaviours and Their Cognitive Correlates in Aging Adults With Down Syndrome.Journal of applied research in intellectual disabilities : JARID · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Fourteen years later: Reviewing the diagnostic criteria for behavioral-variant frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  14. Article
  15. Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  16. Review
  17. Article
  18. Associations of cerebral amyloid beta and tau with cognition from midlife.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  19. Article
  20. Genetic modifiers of cognitive decline in PSEN1 E280A Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shirin SalimiFaculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Muireann IrishSchool of Psychology and Brain & Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
David FoxeSchool of Psychology and Brain & Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
John R HodgesCentral Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Olivier PiguetSchool of Psychology and Brain & Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
James R BurrellCentral Medical School, The University of Sydney, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOverlapping and evolving symptoms lead to ambiguity in the diagnosis of dementia. Visuospatial function relies on parietal lobe function, which may be affected in the early stages of Alzheimer's disease (AD). This review evaluates visuospatial dysfunction in patients with AD, frontotemporal dementia, dementia with Lewy bodies, and vascular dementia to determine the diagnostic and prognostic potential of visuospatial tasks in AD.

methodsA systematic search of studies (1960-2016) investigating visuospatial dysfunction in dementia was conducted.

resultsTests measuring construction, specifically Block Design and Clock Drawing Test, and visual memory, specifically Rey-Osterrieth Complex Figure recall and topographical tasks, show the greatest diagnostic potential in dementia. The Benton visual retention, Doors and People, and topographical memory tests show potential as prognostic markers. DISCUSSION: Tests of visuospatial function demonstrate significant diagnostic and prognostic potential in dementia. Further studies with larger samples of pathologically confirmed cases are required to verify clinical utility.

Indexed as

Alzheimer's diseaseBenton visual retention testClock Drawing TestDementia with Lewy bodiesDiagnosisFrontotemporal dementiaPrognosisRey-Osterrieth Complex FigureVascular dementiaVisual object space perception batteryVisuospatial

Identifiers

PMID29780858
PMCPMC5956809

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.