ArticleOpen forum infectious diseases2018
Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development.
Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01940757 (An Experimental Infection Study of Dermally-applied Infectious Necator Americanus Hookworm Larvae in Hookworm-naïve Adults), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Experimental Infection Study of Dermally-applied Infectious Necator Americanus Hookworm Larvae in Hookworm-naïve Adults
Who cites it
23 citing papers in PubMed.
- Na-GST-1 adsorbed on Alhydrogel co-administered with different Toll-like receptor agonists in hookworm-naive adults using a controlled human infection model in the USA: a phase 2, double-blind, randomised controlled trial.The Lancet. Infectious diseases · 2026Trial
- Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial.The Lancet. Infectious diseases · 2021Trial
- Randomized, Placebo Controlled Trial of Experimental Hookworm Infection for Improving Gluten Tolerance in Celiac Disease.Clinical and translational gastroenterology · 2020Trial
- Zoonotic Parasite Nanovaccines: Progress, Challenges, and Future Perspectives.Integrative zoology · 2026Review
- Advances in vaccine development through the controlled human infection models for hookworm and schistosomiasis.PLoS neglected tropical diseases · 2026Review
- Comparison Between Phenotypic Profile and Functional Aspects of IL-9-Producing Lymphocytes, Th17 and Tfh of Individuals From Endemic and Non-Endemic Areas for Hookworm Infection.Parasite immunology · 2026Article
- Human challenge models for vaccine development-strengths, limitations, and expansion into endemic settings: a HIC-Vac meeting report.Immunotherapy advances · 2025Review
- The mRNA Vaccine Technology Era and the Future Control of Parasitic Infections.Clinical microbiology reviews · 2023Review
- Bioactive Antimicrobial Peptides: A New Weapon to Counteract Zoonosis.Microorganisms · 2022Review
- The production of Necator americanus larvae for use in experimental human infection.Parasites & vectors · 2022Article
- Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis.Parasite immunology · 2022Review
- i2APP: A Two-Step Machine Learning Framework For Antiparasitic Peptides Identification.Frontiers in genetics · 2022Article
- Not All Worms Were Created Equal.Frontiers in immunology · 2022Article
- Experimental human hookworm infection: a narrative historical review.PLoS neglected tropical diseases · 2021Review
- The yin and yang of human soil-transmitted helminth infections.International journal for parasitology · 2021Review
- Identifying novel candidates and configurations for human helminth vaccines.Expert review of vaccines · 2021Article
- Immune System Investigation Using Parasitic Helminths.Annual review of immunology · 2021Review
- Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities.PLoS pathogens · 2020Review
- Fast and fierce versus slow and smooth: Heterogeneity in immune responses to Plasmodium in the controlled human malaria infection model.Immunological reviews · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundControlled human hookworm infection (CHHI) is a central component of a proposed hookworm vaccination-challenge model (HVCM) to test the efficacy of candidate vaccines. Critical to CHHI is the manufacture of
methodscGMP-grade
resultsBoth
conclusionsThe inoculum of 50 CLINICAL TRIALS REGISTRATION: NCT01940757.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.