Evidence map›Paper›PMID 29780691›Full record

ArticleAdvances in bioscience and clinical medicine2018

Understanding D-Ribose and Mitochondrial Function.

Diane E Mahoney, John B Hiebert, Amanda Thimmesch, John T Pierce, James L Vacek, Richard L Clancy, Andrew J Sauer, Janet D Pierce

Open access · diamondAbstract read
In one paragraph

Article in Advances in bioscience and clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 52 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Fumonisin BToxins · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Diane E MahoneyUniversity of Kansas Medical Center, School of Nursing, Kansas, US.
John B HiebertUniversity of Kansas Medical Center, School of Nursing, Kansas, US.
Amanda ThimmeschUniversity of Kansas Medical Center, School of Nursing, Kansas, US.
John T PierceUniversity of Kansas Medical Center, School of Nursing, Kansas, US.
James L VacekUniversity of Kansas Medical Center, Kansas, US.
Richard L ClancyUniversity of Kansas Medical Center, School of Nursing, Kansas, US.
Andrew J SauerCenter for Advanced Heart Failure and Heart Transplantation, Kansas, US.
Janet D PierceUniversity of Kansas Medical Center, School of Nursing, Kansas, US.
University of Kansas Medical Center · US

Funding

Reducing symptom burden in patients with heart failure with preserved ejection fraction using ubiquinol and/or D-riboseR01AG054486 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI PIERCE, JANET DOREEN · 2017 to 2019
$1.7M
NIA NIH HHS R01 AG054486
6 · The paper itself

Abstract

Mitochondria are important organelles referred to as cellular powerhouses for their unique properties of cellular energy production. With many pathologic conditions and aging, mitochondrial function declines, and there is a reduction in the production of adenosine triphosphate. The energy carrying molecule generated by cellular respiration and by pentose phosphate pathway, an alternative pathway of glucose metabolism. D-ribose is a naturally occurring monosaccharide found in the cells and particularly in the mitochondria is essential in energy production. Without sufficient energy, cells cannot maintain integrity and function. Supplemental D-ribose has been shown to improve cellular processes when there is mitochondrial dysfunction. When individuals take supplemental D-ribose, it can bypass part of the pentose pathway to produce D-ribose-5-phosphate for the production of energy. In this article, we review how energy is produced by cellular respiration, the pentose pathway, and the use of supplemental D-ribose.

Indexed as

Adenosine TriphosphateBioenergeticsD-riboseMitochondria

Identifiers

PMID29780691
PMCPMC5959283
OpenAlexW2792490528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.