Evidence map›Paper›PMID 29780557›Full record

ArticleChemical science2018

Pd nanosheets with their surface coordinated by radioactive iodide as a high-performance theranostic nanoagent for orthotopic hepatocellular carcinoma imaging and cancer therapy.

Mei Chen, Zhide Guo, Qinghua Chen, Jingping Wei, Jingchao Li, Changrong Shi, Duo Xu, Dawang Zhou, Xianzhong Zhang, Nanfeng Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Linking In Vivo Imaging to Therapeutic Outcome withInternational journal of molecular sciences · 2026
    Review
  3. Biomaterials for biomarker imaging and detection.Journal of advanced research · 2026
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  9. Exploring innovative strides in radiolabeled nanoparticle progress for multimodality cancer imaging and theranostic applications.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  10. Nanoparticles in Cancer Diagnosis and Treatment.Materials (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mei ChenThe State Key Laboratory for Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , National & Local Joint Engineering Research Center of Preparation Technology of Nanomaterials , Department of Chemistry , Xiamen University , Xiamen 361005 , China . Email: nfzheng@xmu.edu.cn.
Zhide GuoCenter for Molecular Imaging and Translational Medicine , State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics , School of Public Health , Xiamen University , Xiamen 361102 , China . Email: zhangxzh@xmu.edu.cn.
Qinghua ChenState Key Laboratory of Cellular Stress Biology , Innovation Center for Cell Signaling Network , School of Life Sciences , Xiamen University , Xiamen , Fujian 361102 , China.
Jingping WeiThe State Key Laboratory for Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , National & Local Joint Engineering Research Center of Preparation Technology of Nanomaterials , Department of Chemistry , Xiamen University , Xiamen 361005 , China . Email: nfzheng@xmu.edu.cn.
Jingchao LiThe State Key Laboratory for Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , National & Local Joint Engineering Research Center of Preparation Technology of Nanomaterials , Department of Chemistry , Xiamen University , Xiamen 361005 , China . Email: nfzheng@xmu.edu.cn.
Changrong ShiCenter for Molecular Imaging and Translational Medicine , State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics , School of Public Health , Xiamen University , Xiamen 361102 , China . Email: zhangxzh@xmu.edu.cn.
Duo XuCenter for Molecular Imaging and Translational Medicine , State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics , School of Public Health , Xiamen University , Xiamen 361102 , China . Email: zhangxzh@xmu.edu.cn.
Dawang ZhouState Key Laboratory of Cellular Stress Biology , Innovation Center for Cell Signaling Network , School of Life Sciences , Xiamen University , Xiamen , Fujian 361102 , China.
Xianzhong ZhangCenter for Molecular Imaging and Translational Medicine , State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics , School of Public Health , Xiamen University , Xiamen 361102 , China . Email: zhangxzh@xmu.edu.cn.ORCID 0000-0001-8591-8301
Nanfeng ZhengThe State Key Laboratory for Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , National & Local Joint Engineering Research Center of Preparation Technology of Nanomaterials , Department of Chemistry , Xiamen University , Xiamen 361005 , China . Email: nfzheng@xmu.edu.cn.ORCID 0000-0001-9879-4790

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiolabeled nanoparticles (NPs), taking advantage of nanotechnology and nuclear medicine, have shown attractive potential for cancer diagnosis and therapy. However, the high background signal in the liver and long-term toxic effects of radioisotopes caused by the nonselective accumulation of radiolabeled nanoparticles in organs have become the major challenges. Here, we report a pH-sensitive multifunctional theranostic platform with radiolabeled Pd nanosheets through a simple mixture of ultra-small Pd nanosheets and radioisotopes utilizing the strong adsorption of

Identifiers

PMID29780557
PMCPMC5944209

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.