ReviewChemical science2018
C4-H indole functionalisation: precedent and prospects.
Review in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 183 citations in OpenAlex.
- Synthesis and Biological Evaluation of 4‑Bromo-ACS omega · 2026Article
- AgBFChemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Transforming Amino Acids into Serotonin 5-HTJournal of the American Chemical Society · 2025Article
- A Tetrazine-Based Synthesis for Accessing Underutilized Aza-Indole Analogues.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Gold-Catalyzed "Back-to-Front" Synthesis of 4-Silyloxyindoles.Organic letters · 2024Article
- Derivatization of 2,1,3-Benzothiadiazole via Regioselective C-H Functionalization and Aryne Reactivity.The Journal of organic chemistry · 2024Article
- In silico prediction of some pharmacokinetic, safety, biological activity and molecular docking studies of 1-piperazine indole hybrid with nicotinic amide and nicotinic acid and their analogues.SAGE open medicine · 2024Article
- Mono or double Pd-catalyzed C-H bond functionalization for the annulative π-extension of 1,8-dibromonaphthalene: a one pot access to fluoranthene derivatives.Beilstein journal of organic chemistry · 2024Article
- Catalyst- and metal-free C(spScientific reports · 2023Article
- [RhCp*ClACS omega · 2023Review
- Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance.RSC advances · 2023Article
- Directed C-H Functionalization of C3-Aldehyde, Ketone, and Acid/Ester-Substituted Free (NH) Indoles with IodoarenesThe Journal of organic chemistry · 2023Article
- Tandem Iridium-Catalyzed Decarbonylative C-H Activation of Indole: Sacrificial Electron-Rich Ketone-Assisted Bis-arylsulfenylation.Organic letters · 2021Article
- Mechanochemical Solvent-Free Catalytic C-H Methylation.Angewandte Chemie (International ed. in English) · 2021Article
- C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles by tuning Pd catalytic modes: Pd(i)-Pd(ii) catalysisChemical science · 2021Article
- Regiocontrol in the oxidative Heck reaction of indole by ligand-enabled switch of the regioselectivity-determining step.Chemical science · 2020Article
- C7-Indole Amidations and Alkenylations by Ruthenium(II) Catalysis.Angewandte Chemie (International ed. in English) · 2020Article
- Catalytic Au(i)/Au(iii) arylation with the hemilabile MeDalphos ligand: unusual selectivity for electron-rich iodoarenes and efficient application to indoles.Chemical science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C4-decorated indoles feature in a plethora of bioactive and functional compounds of importance to natural product synthesis, material sciences, as well as crop protection and pharmaceutical industries. Traditionally, their syntheses largely involved harsh stoichiometric metalations and radical reactions. However, transition metal catalysed C-H activation has recently evolved into a powerful strategy for the late-stage diversification of indoles at the C4-H position. Modern photoredox, enzymatic and precious transition metal catalysis represent the key stimuli for developing challenging C-C and C-Het bond forming transformations under mild reaction conditions. Herein, we discuss the evolution and application of these methods for the step-economical transformations of otherwise inert C4-H bonds up to December 2017.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.