Evidence map›Paper›PMID 29780505›Full record

ArticleChemical science2018

Macrophage-mediated delivery of light activated nitric oxide prodrugs with spatial, temporal and concentration control.

Michael A Evans, Po-Ju Huang, Yuji Iwamoto, Kelly N Ibsen, Emory M Chan, Yutaka Hitomi, Peter C Ford, Samir Mitragotri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Review
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  5. Article
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  8. Article
  9. Review
  10. Review
  11. Article
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  15. Review
  16. Overcoming biological barriers to improve solid tumor immunotherapy.Drug delivery and translational research · 2021
    Review
  17. Article
  18. Theranostic biomaterials for tissue engineering.Current opinion in biomedical engineering · 2021
    Article
  19. Review
  20. Tailoring Materials for Modulation of Macrophage Fate.Advanced materials (Deerfield Beach, Fla.) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael A EvansDepartment of Chemistry and Biochemistry , University of California, Santa Barbara , Santa Barbara , CA , 93106 USA . Email: ford@chem.ucsb.edu.
Po-Ju HuangDepartment of Chemistry and Biochemistry , University of California, Santa Barbara , Santa Barbara , CA , 93106 USA . Email: ford@chem.ucsb.edu.
Yuji IwamotoDepartment of Chemistry and Biochemistry , Doshisha University , 1-3 Tatara Miyakodani, Kyotanabe , Kyoto 610-0394 , Japan.
Kelly N IbsenDepartment of Chemical Engineering , Center for Bioengineering , University of California, Santa Barbara , Santa Barbara , CA , 93106 USA.
Emory M ChanMolecular Foundry , Lawrence Berkeley National Laboratory , Berkeley , CA , USA.
Yutaka HitomiDepartment of Chemistry and Biochemistry , Doshisha University , 1-3 Tatara Miyakodani, Kyotanabe , Kyoto 610-0394 , Japan.
Peter C FordDepartment of Chemistry and Biochemistry , University of California, Santa Barbara , Santa Barbara , CA , 93106 USA . Email: ford@chem.ucsb.edu.ORCID 0000-0002-5509-9912
Samir MitragotriDepartment of Chemical Engineering , Center for Bioengineering , University of California, Santa Barbara , Santa Barbara , CA , 93106 USA.ORCID 0000-0002-2459-8305

Funding

Spectral Laser Scanning Biological MicroscopeS10OD010610 · OD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI RAVEN, MARY A · 2012 to 2012
$429k
NIH HHS S10 OD010610
6 · The paper itself

Abstract

Nitric oxide (NO) holds great promise as a treatment for cancer hypoxia, if its concentration and localization can be precisely controlled. Here, we report a "Trojan Horse" strategy to provide the necessary spatial, temporal, and dosage control of such drug-delivery therapies at targeted tissues. Described is a unique package consisting of (1) a manganese-nitrosyl complex, which is a photoactivated NO-releasing moiety (photoNORM), plus Nd

Identifiers

PMID29780505
PMCPMC5939611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.