ArticleChemical science2018
Rational design of a water-soluble NIR AIEgen, and its application in ultrafast wash-free cellular imaging and photodynamic cancer cell ablation.
Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- A long-wavelength tetraphenylethylene-derived fluorescent probe for sensitive detection of heparin and protamine.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Review
- Endoplasmic reticulum targeted photosensitizer with high photostability and dual ROS generation for breast cancer PDT via apoptosis and pyroptosis.Materials today. Bio · 2026Article
- AIEgen-mediated integration of plain DNA and hydrophobic compounds enabling three-in-one nanosystems for carrier-free delivery.Journal of nanobiotechnology · 2026Article
- Fluorescence bioimaging of drug nanocarriers based on Förster resonance energy transfer, aggregation-induced emission and aggregation-caused quenching.Acta pharmaceutica Sinica. B · 2026Review
- Dimerization-Enhanced Excimer Probe for Wash-Free Plasma Membrane Fluorescence Imaging.Journal of fluorescence · 2026Review
- Plain DNA and cationic aromatics: a platform to simplify carrier-free delivery systems.Journal of nanobiotechnology · 2025Article
- Developing FRET-based UCNP@SiOMikrochimica acta · 2025Article
- Anionic Surfactant-Triggered Excimer Emission from Dipyrene-Based Amphiphilic Dyes for Wash-Free Cell Membrane Imaging.Journal of fluorescence · 2025Article
- A Diimidazole-Based Amphiphilic Probe for Wash-Free Cell Plasma Membrane Imaging.Journal of fluorescence · 2025Article
- Smart Polymeric Micelles with Aggregation-Induced Emission and pH-Responsive Fluorescence Color Change Behavior for Bioimaging and Cancer Therapy.International journal of molecular sciences · 2025Article
- An ESIPT-Based Fluorescent Probe for Wash-Free Cell Membrane Imaging.Journal of fluorescence · 2025Article
- Wash-free fluorescent tools based on organic molecules: Design principles and biomedical applications.Exploration (Beijing, China) · 2025Review
- Design, Synthesis, and Evaluation of Small Fluorescent Molecules with a 1,1-Dimethylnaphthalen-2-(1Molecules (Basel, Switzerland) · 2024Article
- Charge-regulated fluorescent anchors enable high-fidelity tracking of plasma membrane dynamics during biological events.Chemical science · 2024Article
- Organo-PtAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Thiophene Stability in Photodynamic Therapy: A Mathematical Model Approach.International journal of molecular sciences · 2024Article
- Chemical Regulation of Fluorescence Lifetime.Chemical & biomedical imaging · 2023Review
- Preparation of Tetrandrine Nanocrystals by Microfluidic Method and Its In Vitro and In Vivo Evaluation.AAPS PharmSciTech · 2023Article
- An AIE-active bacterial inhibitor and photosensitizer for selective imaging, killing, and photodynamic inactivation of bacteria over mammalian cells.Bioengineering & translational medicine · 2023Article
- Accurate and Convenient Lung Cancer Diagnosis through Detection of Extracellular Vesicle Membrane Proteins via Förster Resonance Energy Transfer.Nano letters · 2023Article
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Authors and funding
10 authors.
Funding
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Abstract
The synthesis of water-soluble near-infrared (NIR)-emissive fluorescent molecules with aggregation-induced emission (AIE) characteristics and theranostic functions is highly desirable but remains challenging. In this work, we designed and readily prepared for the first time such a molecule with AIE features, good water-solubility and intense emission in the NIR region. This AIE luminogen (AIEgen) is able to specifically "light up" the cell membrane without the involvement of a washing procedure. Interestingly, the staining process can be performed by simply shaking the culture with cells at room temperature for only a few seconds after the addition of the AIEgen, indicating an ultrafast and easy-to-operate staining protocol. This is the first fluorescent "light-up" probe for cell-imaging that allows the combination of a short staining period (at the second-level) with a wash-free process. Additionally, the presented AIEgen has also been developed to serve as an excellent phototherapeutic agent for high efficiency generation of reactive oxygen species (ROS) upon visible light irradiation, which allows its effective application in the photodynamic ablation of cancer cells, demonstrating its dual role as an imaging and phototherapeutic agent.
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